Tian-Lu Cheng  Professor
Department of Biomedical Science and Environmental Biology, Kaohsiung Medical
University, Kaohsiung, Taiwan
Phone: 886-7-3121101-2147 or 2697
Fax: 886-7-3227508

E-mail: tlcheng@kmu.edu.tw or tlcheng5024@gmail.com

Academia Sinica and National Defense Medical Center
Republic of China (Taiwan)
Graduate Institute of Life Science
From 1995/8 to 1999/7
National Defense Medical Center
Republic of China (Taiwan)
Microbiology and Immunology
From 1991/8 to 1993/7
Kaohsiung Medical College
Republic of China (Taiwan)
Medical Technology
From 1987/9 to 1991/6
Courses Offered:
Immunology, Cancer biology, Biology, Biomedical journal club
1. Humanized Antibody engineering, 2.Functional molecular imaging, 3.Tumor immunology, 4.Gene therapy, 5.Functional genomics, 6. Protein/antibody drugs
2008~2014 Publications

2014 publications

  1. Cheng CM, Tzou SC, Zhuang YH, Huang CC, Kao CH, Liao KW, Cheng TC, Chuang CH, Hsieh YC, Tai MH, Cheng TL*. Functional production of a soluble and secreted single-chain antibody by a bacterial secretion system. PLoS One. 2014 May 13;9(5):e97367
  2. Chen YJ, Lin HC, Chen KC, Lin SR, Cheng TL, Chang LS. Taiwan cobra phospholipase A<sub>2</sub> suppresses ERK-mediated ADAM17 maturation, thus reducing secreted TNF-α production in human leukemia U937 cells. Toxicon. 2014 May 27;86C:79-88.
  3. Su YC, Al-Qaisi TS, Tung HY, Cheng TL, Chuang KH, Chen BM, Roffler SR. Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies. MAbs. 2014 May 14;6(4).
  4. Chuang CH, Wang WJ, Li CF, Ko CY, Chou YH, Chuu CP, Cheng TL*, Wang JM*. The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer. Cell Death Dis. 2014 May 8;5:e1220
  5. Chen YJ, Wu SC, Chen CY, Tzou SC, Cheng TL, Huang YF, Yuan SS, Wang YM. Peptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection. Biomaterials. 2014 Jan;35(1):304-15.

2013 publications

  1. Cheng TC, Chuang KH, Chen M, Wang HE, Tzou SC, Su YC, Chuang CH, Kao CH, Chen BM, Chang LS, Roffler SR, Cheng TL*. Sensitivity of PEGylated interferon detection by anti-polyethylene glycol (PEG) antibodies depends on PEG length. Bioconjug Chem. 2013 Aug 5. [Epub ahead of print]
  2. Liu WH, Chen YJ, Cheng TL, Lin SR, Chang LS. Cross talk between p38MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit α and MAPK phosphatase-1 expression in human leukemia U937 cells. Cell Signal. 2013 Sep;25(9):1845-51
  3. Chen SH, Kuo YT, Cheng TL, Chen CY, Chiu YY, Lai JJ, Chang CC, Jaw TS, Wang YM, Liu GC. In vivo magnetic resonance imaging of mice liver tumors using a new gadolinium-based contrast agent. Kaohsiung J Med Sci. 2013 May;29(5):246-53.
  4. Cheng CM, Chen FM, Lu YL, Tzou SC, Wang JY, Kao CH, Liao KW, Cheng TC, Chuang CH, Chen BM, Roffler S, Cheng TL*. Expression of β-glucuronidase on the surface of bacteria enhances activation of glucuronide prodrugs. Cancer Gene Ther. 2013 May;20(5):276-81
  5. Wu SC, Lin KL, Wang TP, Tzou SC, Singh G, Chen MH, Cheng TL, Chen CY, Liu GC, Lee TW, Hu SH, Wang YM. Imaging specificity of MR-optical imaging agents following the masking of surface charge by poly(ethylene glycol). Biomaterials. 2013 May;34(16):4118-27.
  6. Lu CY, Tsai HL, Uen YH, Hu HM, Chen CW, Cheng TL, Lin SR, Wang JY. Circulating tumor cells as a surrogate marker for determining clinical outcome to mFOLFOX chemotherapy in patients with stage III colon cancer. Br J Cancer. 2013 Mar 5;108(4):791-7.

2012 publications

  1. Chen SH, Kuo YT, Singh G, Cheng TL, Su YZ, Wang TP, Chiu YY, Lai JJ, Chang CC, Jaw TS, Tzou SC, Liu GC, Wang YM. Development of a Gd(III)-Based Receptor-Induced Magnetization Enhancement (RIME) Contrast Agent for β-Glucuronidase Activity Profiling. Inorg Chem. 2012 Nov 1. [Epub ahead of print] 2011 IF=4.601, (4/44=9%) in CHEMISTRY, INORGANIC & NUCLEAR
  2. Lin YJ, Liu YS, Yeh HH, Cheng TL, Wang LF. Self-assembled poly(ε-caprolactone)-g-chondroitin sulfate copolymers as an intracellular doxorubicin delivery carrier against lung cancer cells. Int J Nanomedicine. 2012;7:4169-83. 2011 IF=3.130, (70/261=26.8%) in PHARMACOLOGY & PHARMACY
  3. Chen CH, Liu YK, Lin YL, Chuang HY, Hsu WT, Chiu YH, Cheng TL, Liao KW.A rapid and convenient method to enhance transgenic expression in target cells. Prep Biochem Biotechnol. 2012;42(5):448-61. 2011 IF=0.466, (279/290=96.2%) in BIOCHEMISTRY & MOLECULAR BIOLOGY
  4. Kao CH, Cheng CM, Chuang KH, Chuang CH, Tzou SC, Cheng TC, Hsieh YC, Liao KW, Wang YM, Chang LS, Roffler SR, Chen FM, Cheng TL*. A regularly spaced and self-revealing protein ladder for anti-tag Western blot analysis. Anal Biochem. 2012 Dec 1;431(1):1-3. 2011 IF=2.996 (19/73=26%) in CHEMISTRY, ANALYTICAL
  5. Chen CP, Hsieh YT, Prijovich ZM, Chuang HY, Chen KC, Lu WC, Tseng Q, Leu YL, Cheng TL, Roffler SR. ECSTASY, an adjustable membrane-tethered/soluble protein expression system for the directed evolution of mammalian proteins. Protein Eng Des Sel. 2012 25(7):367-75. 2011 IF=2.937, (47/160=29.3%) in Biotechnology & Applied Microbiology
  6. Cheng TL, Chuang KH, Chen BM, Roffler SR. Analytical Measurement of PEGylated Molecules. Bioconjug Chem. 2012 Feb 2. 23, 881−899. 2011 IF: 4.930 (8/56=14.2%) CHEMISTRY, ORGANIC
  7. Ta-Chun Cheng, Steve R. Roffler, Shey-Cherng Tzou, Kuo-Hsiang Chuang, Yu-Cheng Su, Chih-Hung Chuang, Chien-Han Kao, Chien-Shu Chen,I-Hong Harn, Kuan-Yi Liu, Tian-Lu Cheng* and Yu-Ling Leu*. An Activity-Based Infrared Glucuronide Trapping Probe for Imaging b-Glucuronidase Expression in Deep Tissues. J. Am. Chem. Soc. 2012, 134, 3103−3110. 2011 IF=9.907, (11/154=7.1%) in CHEMISTRY, MULTIDISCIPLINARY
  8. CH Chuang, KH Chuang, HE Wang, SR Roffler, SC Tzou, TC Cheng, CH Kao, SY Wu, WL Tseng, J Shiea, JM Wang* and TL Cheng*. In vivo PET Imaging of protease activity by hydrophilic-to-hydrophobic conversion of a protease substrate. Clin Cancer Res. 2012 Jan 1;18(1):238-247. 2011 IF=7.742, (14/196=7.1%) in ONCOLOGY
  9. Chen CH, Lin YL, Liu YK, He PJ, Lin CM, Chiu YH, Wu CJ, Cheng TL, Liu SJ, Liao KW. Liposome-based polymer complex as a novel adjuvant: enhancement of specific antibody production and isotype switch. Int J Nanomedicine. 2012;7:607-21. Epub 2012 Feb 3.
  10.  Huang MY, Wang HM, Tok TS, Chang HJ, Chang MS, Cheng TL, Wang JY, Lin SR. EVI2B, ATP2A2, S100B, TM4SF3, and OLFM4 As Potential Prognostic Markers for Postoperative Taiwanese Colorectal Cancer Patients. DNA Cell Biol. 2012 Apr;31(4):625-35.

2011 publications

  1. Kasala D, Lin TS, Chen CY, Liu GC, Kao CL, Cheng TL, Wang YM. [Gd(Try-TTDA)(H2O)]2-: a new MRI contrast agent for copper ion sensing. Dalton Trans. 2011 May 14;40(18):5018-25.
  2. Tseng FJ, Liu YK, Chung YS, Lin YL, Chen CH, Wang WY, Chen YC, Tsai NM, Cheng TL, Pan RY, Hu TM, Lee RP, Liao KW A fusion protein composed of receptor binding domain of vascular endothelial growth factor-A and constant region fragment of antibody: angiogenesis antagonistic activity. Cytotechnology. 2011 May;63(3):285-93.
  3. Chen KC, Wu SY, Leu YL, Prijovich ZM, Chen BM, Wang HE, Cheng TL, Roffler SR. A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment. Bioconjug Chem. 2011 May 18;22(5):938-48.
  4. Huang PT, Chen KC, Prijovich ZM, Cheng TL, Leu YL, Roffler SR.Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of β-glucuronidase in tumors. Cancer Gene Ther. 2011 Jun;18(6):381-9.
  5. Liu YK, Lin YL, Chen CH, Lin CM, Ma KL, Chou FH, Tsai JS, Lin HY, Chen FR, Cheng TL, Chang CC, Liao KW A unique and potent protein binding nature of liposome containing polyethylenimine and polyethylene glycol: a nondisplaceable property. Biotechnol Bioeng. 2011 Jun;108(6):1318-27

2010 publications

  1. Kuo-Hsiang Chuang, Hsin-Ell Wang, Ta-Chun Cheng, Shey-Cherng Tzou, Chiu-Min Cheng, Chien-Han Kao, Chih-Hung Chuang3, Wei-Lung Tseng, Wen-Chun Hung, Ming-Hong Tai, Tien-Kuei Chang, Bing-Mae Chen, Steve R. Roffler and Tian-Lu Cheng*. Development of an Universal Anti-Polyethylene Glycol Reporter Gene for Noninvasive Imaging of PEGylated Probes. Journal of Nuclear Medicine, 2010, 51:933-941 2009IF: 6.424 (1/104 0.96%) RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
  2. Kuo-Hsiang Chuang, Shey-Cherng Tzou, Ya-Chen Chang, Chien-Han Kao, Kuang-Wen, Liao, Ta-Chun Cheng, Bo-Jyun Huang, Chang-Jer Wu, Wei-Lung Tseng, Jentaie Shiea, Pei-Yu Chu, Steve Roffler, Tian-Lu Cheng* Measurement of Free Polyethylene Glycol by a Novel Cell-Based Anti-Polyethylene Glycol ELISA. Anal Chem. 2010 Mar 15;82(6):2355-62. 2009IF: 5.214 (3/70 4.29%) CHEMISTRY, ANALYTICAL
  3. Kuo-Hsiang Chuang, Hsin-Ell Wang, Fang-Ming Chen, Shey-Cherng Tzou, Chiu-Min Cheng, Ya-Chen Chang, Wei-Lung Tseng, Jentaie Shiea, Shiu-Ru Lin, Jaw-Yuan Wang, Bing-Mae Chen, Steve R. Roffler and Tian-Lu Cheng*. Endocytosis of PEGylated agents enhances cancer imaging and anti-cancer efficacy. Molecular cancer therapeutics, 2010, 9(6);1903-1912 2009IF: 4.953 (27/165 16.36%) ONCOLOGY
  4. Tsao DA, Chang HJ, Lin CY, Hsiung SK, Huang SE, Ho SY, Chang MS, Chiu HH, Chen YF, Tian-Lu Cheng*, Shiu-Ru L. Gene expression profiles for predicting the efficacy of the anticancer drug 5-fluorouracil in breast cancer. DNA Cell Biol. 2010 Jun;29(6):285-93. 2009IF: 2.280 (170/283 60.07%) BIOCHEMISTRY & MOLECULAR BIOLOGY
  5. Su YC, Chen BM, Chuang KH, Tian-Lu Cheng*, Roffler SR. Sensitive Quantification of PEGylated Compounds by Second-Generation Anti-Poly(ethylene glycol) Monoclonal Antibodies. Bioconjug Chem. 2010 Jul 21;21(7):1264-70. 2009IF: 4.305 (7/57 12.28%) CHEMISTRY, ORGANIC
  6. Chung FY, Cheng TL, Chang HJ, Chiu HH, Huang MY, Chang MS, Chen CC, Yang MJ, Wang JY, Lin SR. Differential gene expression profile of MAGE family in taiwanese patients with colorectal cancer. J Surg Oncol. 2010 Aug 1;102(2):148-53. 2009IF: 2.502 (37/166 22.29%) SURGERY
  7. Yu CJ, Lin CY, Liu CH, Cheng TL, Tseng WL. Synthesis of poly(diallyldimethylammonium chloride)-coated Fe(3)O(4) nanoparticles for colorimetric sensing of glucose and selective extraction of thiol. Biosens Bioelectron. 2010 Oct 15;26(2):913-7.. 2009IF: 5.429 (2/70 2.86%) CHEMISTRY, ANALYTICAL
  8. Yang Yu Hsiang, Yung-Hsin Wang, Jaw-Yuan Wang, Fang-Ming Chen, Wei-Lung Tseng, Che-Hsin Lin, Ming-Chia Hsieh, Ming-Yii Huang, Shiu-Ru Lin and Tian-Lu Cheng*. Simultaneous detection of multiple single nucleotide polymorphisms by a simple SNP chip. Genet Test Mol Biomarkers. 2010 Oct;14(5):653-9. 2009 IF1.17 (119/14681.5) GENETICS & HEREDITY
  9. Li YC, Chen BM, Wu PC, Cheng TL, Kao LS, Tao MH, Lieber A, Roffler SR. Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling.. J Immunol. 2010 Jun 1;184 (11):5959-63.2009IF: 5.646 (18/128 14.06%) IMMUNOLOGY
  10. Lin CS, He PJ, Tsai NM, Li CH, Yang SC, Hsu WT, Wu MS, Wu CJ, Cheng TL, Liao KW. A potential role for Helicobacter pylori heat shock protein 60 in gastric tumorigenesis. Biochem Biophys Res Commun. 2010 Feb 5;392(2):183-9. 2009IF: 2.548 (146/283 51.59%) BIOCHEMISTRY & MOLECULAR BIOLOGY
  11. Lin LF, Chuang CH, Li CF, Liao CC, Cheng CP, Cheng TL, Shen MR, Tseng JT, Chang WC, Lee WH, Wang JM. ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer. Cancer Res. 2010 Jan 1;70(1):192-201. 2009IF: 7.543 (13/16 7.88%) ONCOLOGY

2009 publications

  1. Shey-Cherng Tzou, Steve Roffler, Kuo-Hsiang Chuang, Hsin-Pei Yeh, Chien-Han Kao, Yu-Cheng Su, Chiu-Min Cheng, Wei-Lung Tseng, Jentaie Shiea, Kai-Wen Cheng, Bing-Mae Chen, Tian-Lu Cheng*and Hsin-Ell Wang. Micro-PET imaging of b-glucuronidase activity by the hydrophobic conversion of a glucuronide probe. Radiology, 2009, Sep;252(3):754-62.2009IF: 6.341 (2/104 1.92%) RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
  2. Chiu-Min Cheng, Pei-Yu Chu, Kuo-Hsiang Chuang, Steve R. Roffler, Chien-Han Kao, Wei-Lung Tseng, Jentaie Shiea, Wen-Da Chang, Yu-Cheng Su, Bing-Mae Chen, Yun-Ming Wang and Tian-Lu Cheng*. Hapten-derivatized nanoparticle targeting and imaging of gene expression by multimodality imaging systems. Cancer gene therapy, 2009 Jan;16(1):83-90. (2009IF: 3.126 (41/150 27.33%) BIOTECHNOLOGY & APPLIED MICROBIOLOGY
  3. Chen YM, Cheng TL, Tseng WL. Fluorescence turn-on detection of iodide, iodate and total iodine using fluorescein-5-isothiocyanate-modified gold nanoparticles. Analyst. 2009 Oct;134(10):2106-12. 2009IF: 3.272 (11/70 15.71%) CHEMISTRY, ANALYTICAL
  4. Li MD, Tseng WL, Cheng TL. Ultrasensitive detection of indoleamines by combination of nanoparticle-based extraction with capillary electrophoresis/laser-induced native fluorescence. J Chromatogr A. 2009 Sep 4;1216(36):6451-8.2009IF: 4.101 (4/70 8.5%) CHEMISTRY, ANALYTICAL
  5. Yu CJ, Cheng TL, Tseng WL. Effects of Mn2+ on oligonucleotide-gold nanoparticle hybrids for colorimetric sensing of Hg2+: improving colorimetric sensitivity and accelerating color change. Biosens Bioelectron. 2009 Sep 15;25(1):204-10.2009IF:5.429 (2/70 2.86%)CHEMISTRY, ANALYTICAL
  6. Chung FY, Huang MY, Yeh CS, Chang HJ, Cheng TL, Yen LC, Wang JY, Lin SR. GLUT1 gene is a potential hypoxic marker in colorectal cancer patients. BMC Cancer. 2009 Jul 20;9:241.2009IF: 2.736 (71/165 43.03%) ONCOLOGY
  7. Liu GS, Huang HT, Lin CJ, Shi JY, Liu LF, Tseng RT, Weng WT, Lam HC, Wen ZH, Cheng TL, Hsu KS, Tai MH. Prophylactic Proopiomelanocortin Expression Alleviates Capsaicin-Induced Neurogenic Inflammation in Rat Trachea. Shock. 2009 Dec;32(6):645-50.2008IF: 2.871 (23/166 13.86%) SURGERY
  8. Cheng SC, Cheng TL, Chang HC, Shiea J. Using laser-induced acoustic desorption/electrospray ionization mass spectrometry to characterize small organic and large biological compounds in the solid state and in solution under ambient conditions. Anal Chem. 2009 Feb 1;81(3):868-74.2009IF: 5.214 (3/70 4.29%) CHEMISTRY, ANALYTICAL
  9. Li MD, Cheng TL, Tseng WL. Nonionic surfactant-capped gold nanoparticles for selective enrichment of aminothiols prior to CE with UV absorption detection. Electrophoresis. 2009 Jan;30(2):388-95. 2009IF: 3.077 (13/70 18.57%) CHEMISTRY, ANALYTICAL
  10. Chen TJ, Cheng TH, Chen CY, Hsu SC, Cheng TL, Liu GC, Wang YM. Targeted Herceptin-dextran iron oxide nanoparticles for noninvasive imaging of HER2/neu receptors using MRI. J Biol Inorg Chem. 2009 Feb;14(2):253-60. 2009IF: 3.415 (8/44 18.189%) CHEMISTRY, INORGANIC & NUCLEAR

2008 Publications

  1. Tian-Lu Cheng and Steve Roffler. Membrane-tethered proteins for basic research, imaging and therapy. Medicinal Research Reviews, 2008, Nov;28(6):885-928 2009IF: 8.656 (8/236 3.39%) PHARMACOLOGY & PHARMACY
  2. Chiu-Min Cheng, Yu-Ling Lu , Kuo-Hsiang Chuang,Wen-Chun Hung, Jentaie Shiea, Yu-Cheng Su, Chien-Han Kao, Bing-Mae Chen, Steve Roffler and Tian-Lu Cheng* Tumor-targeting prodrug-activating bacteria for cancer therapy. Cancer Gene Ther. 2008, Jun;15(6):393-401. 2009IF: 3.126 (41/150 27.33%) BIOTECHNOLOGY & APPLIED MICROBIOLOGY
  3. Cheng CY, Yuan CH, Cheng SC, Huang MZ, Chang HC, Cheng TL, Yeh CS, Shiea J. Electrospray-assisted laser desorption/ionization mass spectrometry for continuously monitoring the states of ongoing chemical reactions in organic or aqueous solution under ambient conditions. Anal Chem. 2008 Oct 15;80(20):7699-705. 2009IF: 5.214 (3/70 4.29%) CHEMISTRY, ANALYTICAL
  4. Wu HP, Huang CC, Cheng TL, Tseng WL. Sodium hydroxide as pretreatment and fluorosurfactant-capped gold nanoparticles as sensor for the highly selective detection of cysteine. Talanta. 2008 Jul 15;76(2):347-52. 2009IF: 3.290 (9/70 12.86%) CHEMISTRY, ANALYTICAL
  5. Uen YH, Lu CY, Tsai HL, Yu FJ, Huang MY, Cheng TL, Lin SR, Wang JY. Persistent Presence of Postoperative Circulating Tumor Cells is a Poor Prognostic Factor for Patients with Stage I-III Colorectal Cancer after Curative Resection. Ann Surg Oncol. 2008, Aug;15(8):2120-8.2009IF: 4.130 (6/166 3.61%)SURGERY
  6. Liu FC, Cheng TL, Shen CC, Tseng WL, Chiang MY. Synthesis of Cysteine-Capped Zn(x)Cd(1)(-)(x)Se alloyed quantum dots emitting in the blue-green spectral range. Langmuir. 2008 Mar 4; 24(5):2162-7. 2009IF:3.898 (25/212 11.79%)MATERIALS SCIENCE, MULTIDISCIPLINARY
  7. Chen YM, Yu CJ, Cheng TL, Tseng WL. Colorimetric detection of lysozyme based on electrostatic interaction with human serum albumin-modified gold nanoparticles. Langmuir. 2008 Apr 1; 24(7):3654-60. 2009IF:3.898 (25/212 11.79%)MATERIALS SCIENCE, MULTIDISCIPLINARY
  8. Huang MY, Wang YH, Chen FM, Lee SC, Fang WY, Cheng TL, Hou MF, Wang JY, Lin SR. Multiple Genetic Polymorphisms of GSTP1 313AG, MDR1 3435CC, and MTHFR 677CC highly correlated with early relapse of breast cancer patients in Taiwan. Ann Surg Oncol. 2008 Mar;15(3):872-80. 2009IF: 4.130 (6/166 3.61%)SURGERY
  9. Huang MY, Fang WY, Lee SC, Cheng TL, Wang JY, Lin SR. ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study. BMC Cancer. 2008 Feb 12;8:50. 2009IF: 2.736 (71/165 43.03%) ONCOLOGY
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