Li, Ruei-Nian／Associate Professor

Associate Professor Li, Ruei-Nian
E-mail:runili@kmu.edu.tw
Education:
PhD, National Yang-Ming University, R.O.C.
Courses Offered:
Biology , Virology, Microbiology, Microbial Genetics , Modern Biotechnology
Specialty:
Molecular Virology, Microbiology
Academic Interests:
Molecular Virology
Cancer Biology
Publications:

  1. Ruei-Nian Li, Tsan-Teng Ou, Chia-Hui Lin, Yuan-Zhao Lin, Tzu-Jung Fang, Yi-Jing Chen, Chia-Chun Tseng, Wan-Yu Sung, Cheng-Chin Wu, Jeng-Hsien Yen. NLRP3 gene polymorphisms in Rheumatoid Arthritis and Primary Sjogren's Syndrome patients. Diagnostics (2023), 13(2):206.

  2. Yung-Ding Bow, Ching-Chung Ko, Wen-Tsan Chang, Sih-Yan Chou, Chun-Tzu Hung, Jau-Ling Huang, Chih-Hua Tseng, Yeh-Long Chen, Ruei-Nian Li and Chien-Chih Chiu. A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage. Cancer Cell International (2023), 23:171.

  3. Wan-Yu Sung, Yuan-Zhao Lin, Daw-Yang Hwang, Chia-Hui Lin, Ruei-Nian Li, Chia-Chun Tseng, Cheng-Chin Wu, Tsan-Teng Ou and Jeng-Hsien Yen (2022, Dec). Methylation of TET2 Promoter Is Associated with Global Hypomethylation and Hypohydroxymethylation in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients. Diagnostics 2022, 12:3006.

  4. Tzu-Jung Fang, Chia-Hui Lin, Yuan-Zhao Lin, Min-HSi Chiu, Ruei-Nian Li, Hua-Chen Chan, Yao-Tsung Yeh, Jeng-Hsien Yen (2022, Aug). Lower HDAC6 mRNA expression and promoter hypomethylation are associated with RA susceptibility. Journal of the Formosan Medical Association 2022, 121(8):1431-1441.

  5. Ruei-Nian Li, Po-Tsun Shen, Hugo You-Hsien Lin & Shih-Shin Liang. Shotgun proteomic analysis using human serum from type 2 diabetes mellitus patients. International Journal of Diabetes in Developing Countries 2022, s13410-021-01038-z.

  6. Chia-Chun Tseng, Yuan-Zhao Lin, Chia-Hui Lin, Daw-Yang Hwang, Ruei-Nian Li, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Yu-Chih Lin, Wan-Yu Sung, Kuan-Yu Chen, Shun-Jen Chang, Jeng-Hsien Yen. Genetic and epigenetic alterations of cyclic AMP response element modulator in rheumatoid arthritis. European Journal of Clinical Investigation 2021, 16:e13715.
  7. Tzu-Jung Fang, Chia-Hui Lin, Yuan-Zhao Lin, Min-HSi Chiu, Ruei-Nian Li, Hua-Chen Chan, Yao-Tsung Yeh, Jeng-Hsien Yen. Lower HDAC6 mRNA expression and promoter hypomethylation are associated with RA susceptibility. Journal of The Formosan Medical Association 2021, 31:S0929-6646(21)00480-0.
  8. Sheng-Chieh Wang, Ruei-Nian Li, Li-Ching Lin, Jen-Yang Tang, Jui-Hsin Su, Jyh-Horng Sheu, Hsueh-Wei Chang. Comparison of Antioxidant and Anticancer Properties of Soft Coral-Derived Sinularin and Dihydrosinularin. Molecules 2021, 26(13): 3853.
  9. Sheng-Yao Peng, Jen-Yang Tang, Ruei-Nian Li, Hurng-Wern Huang, Chang-Yi Wu, Chien-Chih Chiu, Fang-Rong Chang, Hong-Wei Zhang, Yun-Jou Lee, Jyh-Horng Sheu, Hsueh-Wei Chang. Oxidative Stress-Dependent Synergistic Antiproliferation, Apoptosis, and DNA Damage of Ultraviolet-C and Coral-Derived Sinularin Combined Treatment for Oral Cancer Cells. Cancers 2021, 13(10):2450.
  10. Yen-Yun Wang, Yuk-Kwan Chen, Steven Lo, Tsung-Chen Chi, Yi-Hua Chen, Stephen Chu-Sung Hu, Ya-Wen Chen, Shih Sheng Jiang, Fang-Yu Tsai, Wangta Liu, Ruei-Nian Li, Ya-Ching Hsieh, Chih-Jen Huang, Shyng-Shiou F Yuan. MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner. Oncogene 2021, 40(20):3510-3532.
  11. Hua-Chen Chan, Shu-Chen Wang, Chia-Hui Lin, Yuan-Zhao Lin, Ruei-Nian Li, Jeng-Hsien Yen. A novel CD209 polymorphism is associated with rheumatoid arthritis patients in Taiwan. Journal of Clinical Laboratory 2021, 35(5):e23751
  12. Tzu-Jung Fang, Ruei-Nian Li, Yuan-Zhao Lin, Chia-Hui Lin, Chia-Chun Tseng, Wan-Yu Sung, Tsan-Teng Ou, Cheng-Chin Wu, Jeng-Hsien Yen. Association of F11R polymorphisms and gene expression with primary Sjögren's syndrome patients. International Journal of Rheumatic Diseases 2021, 24(5):681-686.
  13. Yung-ding Bow, Yen-yun Wang, Yuk-kwan Chen, Chang-Wei Su,Ching-Wei Hsu, Shyng-shiou Yuan and Ruei-nian Li. Silencing of FOXA2 decreases E-cadherin expression and promotes metastasis in oral cancer. Oral Diseases 2020, 26:756-765.
  14. Ruei-nian Li, Chien-yu Li, Chien-hung Lee, Chiung-yu Peng, and Ming-Tsang Wu*. Promoter methylation status of tumor suppressor genes p16 and CDH1 in cervical intraepithelial neoplasia. Oncology Letters 2017, 13(6):4397-4401.
  15. Tzu-Jung Fang, Yuan-Zhao Lin, Ching-Ching Liu, Chia-Hui Lin, Ruei-Nian Li, Cheng-Chin Wu, Tsan-Teng Ou, Wen-Chan Tsai and Jeng-Hsien Yen. Methylation and gene expression of histone deacetylases 6 in systemic lupus erythematosus. International Journal of Rheumatic Diseases 2016, 19: 968-973.
  16. Chien-Hung Lee, Chiung-Yu Peng, Ruei-Nian Li Yu-Chieh Chen, Hsiu-Ting Tsai, Yu-Hsiu Hung, Te-Fu Chan, Hsiao-Ling Huang, Tai-Cheng Lai and Ming-Tsang Wu. Risk evaluation for the development of cervical intraepithelial neoplasia: Development and validation of risk-scoring schemes. International Journal of Cancer 2015, 136(2):340-345.
  17. Lihua Lu, Li-Juan Liu, Wei-chieh Chao, Hai-Jing Zhong, Modi Wang, Xiu-Ping Chen, Jin-Jian Lu, Ruei-nian Li*, Dik-Lung Ma* and Chung-Hang Leung*. Identification of an iridium (III) complex with anti-bacterial and anti-cancer activity. Scientific Reports 2015, 5:14544-1455.
  18. Ruei-nian Li, Fang-Jung Yu, Chun-Chieh Wu, Yu-Kuei Chen, Chun-Chieh Yu, Shah-Hwa Chou, Jui-Ying Lee, Yu-Jen Cheng, Ming-Tsang Wu and I-Chen Wu*. Methylation status of retinoic acid receptor beta2 promoter and global DNA in esophageal squamous cell carcinoma. Journal of Surgical Oncology 2014, 109:623-627.
  19. Yuan-Zhao Lin, Ruei-Nian Li, Chia-Hui Lin, Tsan-Teng Ou, Cheng-Chin Wu, Wen-Chan Tsai, Hong-Wen Liu and Jeng-Hsien Yen. Association of OSMR gene polymorphisms with Rheumatoid Arthritis and Systemic Lupus Erythematosus patients. Autoimmunity 2014, 47(1): 23-26.
  20. Ruei-nian Li, Chin-jen Wu, Zong-jing Yu, Hsueh-wei Chang and *Shih-shin Liang. Networks development between nicotinic chemical probes and CA9-22 oral cancer cells by general proteomics analyses. Electrophoresis 2014, 35:2213-2221.
  21. PJ Yang, RN Li, CC Huang, TH Wang, YC Ko, MS Huang and TN Wang. The methylation pattern of a disintegrin and metalloproteinase 33 gene (ADAM33) in adult asthma. International Archives of Allergy and Immunology 2013, 161:74-80.
  22. Ching-ching Liu, Tsan-teng Ou, Cheng-ching Wu, Ruei-nian Li, Yu-chih Lin, Chia-hui Lin, Wen-chan Tsai, Hong-wen Liu and *Jeng-hsien Yen. Global DNA methylation, DNMT1 and MBD2 in patients with Rheumatoid Arthritis. Immunology Letters 2011, 135:96-99.
  23. Chien-hung Lee, Sheau-fang Yang, Chiung-yu Peng, Ruei-nian Li, Yu-chieh Chen, Te-fu Chan, Eing-mei Tsai, Fu-chen Kuo, Joh-jong Huang,Hsiu-ting Tsai, Yu-hsiu Hung, Hsiao-ling Hunag, Sharon Tsai and *Ming-tsang Wu. The precancerous effect of emitted cooking oil fumes on precursor lesions of cervical cancer. International Journal of Cancer 2010, 127:932-941. (Impact factor: 4.722, Ranking: 29/165)
  24. Ruei-nian Li, Yu-hung Hung, Chia-hui Lin, Yen-hsu Chen, and *Jeng-hsien Yen. Inhibitor IkBa promoter functional polymorphisms in patients with Rheumatoid Arthritis. Journal of Clinical Immunology 2010, 30:676-680. (Impact factor: 3.583, Ranking: 38/128)
  25. Yu-Hung Hung, Cheng-Chin Wu, Tsan-Teng Ou, Chia-Hui Lin, Ruei-Nian Li, Yu-Chih Lin, Wen-Chan Tsai, Hong-Wen Liu, Jeng-Hsien Yen Dieases Markers. 2010, 28(1):55-62.(Impact Factor: 2.026; Ranking: 70/150).
  26. Yu-hsiang Yang, Ruei-nian Li, Shey-cherng Tzou, Jaw-yuan Wang, Hsin-pai Lee, Hsien-chung Wang, Fang-ming Chen, Yung-hsin Wang, Ming-chia Hsieh,Ming-yii Wang, Wei-lung Tseng, Shiou-ru Lin and *Tian lu Cheng. Simultaneous detection of multiple single-nucleotide polymorphisms by a simple membrane chip. Genetic Testing and Molecular Biomarkers 2010, 14:653-659. (Impact factor: 1.17, Ranking: 119/146)
  27. Chia-hui Lin, Shu-chen Wang, Tsan-teng Ou, Ruei-nian Li, Wen-chan Tsai, Hong-wen Liu and *Jeng-hsien Yen. IkappaBalpha promoter polymorphisms in patients with systemic lupus erythematosis. Journal of Clinical Immunology 2008, 28:207-213.
  28. Shu-chen Wang, Chia-hui Lin, Ruei-nian Li, Tsan-teng Ou, Cheng-chin Wu, Wen-chan Tsai, Hong-wen Liu and *Jeng-hsien Yen. Polymorphisms of genes for programmed cell death 1 ligands in patients with rheumatoid arthritis. Journal of Clinical Immunology 2007, 27:563-567.
  29. Yueh-sheng Chen, Pei-hsi Chou, Shui-nin Li, Wen-chan Tsai, Kuei-hsiang Lin, Kun-bow Tsai, Jeng-hsien Yen and Hong-wen Liu. Parvovirus B19 infection in patients with rheumatoid arthritis in Taiwan. J Rheumatol 2006; 33:887-891.(Impact factor: 3.01;Ranking in Rheumatal:7/22)
  30. Hsiu-ting Tsai, Ching-hu Wu, Hsiao-ling Lai, Ruei-nian Li, Yi-ching Tung, Hung-yi Chuang, Trong-neng Wu, Li-jen Lin, Chi-kung Ho, Hon-wein Liu and Ming-tsang Wu. Association between quantitative high-risk Human papillomavirus DNA load and cervical intraepithelial neoplasm risk. Cancer epidemiology Biomarkers and Prevention 2005; 14:2544-2549. (Impact factor: 4.5)
  31. Kuan-yuan Wang, Shui-nin Li, Chiang-shin Liu, Daw-shyong Perng, Yu-chung Su, Deng-chyang Wu, Chang-ming Jan, Chun-huang Lai, Tsu-nai Wang, and Wen-ming Wang. Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori.(2004) Am. J. Clin. Nutr. 80:737-741.
  32. Hui-hsien Chiu, Po-han Huang, Hsiu-yu Huang, Shui-nin Li, Ji-chen Ho. Nasal T/NK cell lymphoma associated with Epstein-Barr virus infection in two cases of lethal midline granuloma. Dermatologica Sinica 2000; 18:88-94.
  33. Te-shien Yeh, Shui-nin Li, Chang-jer Wu, Shih-tung Liu, Ching-liang Meng and Yu-cun Chang. Sequence variations between two Epstein-Barr virus LMP1 variants have no effect on the activation of NF-kB activity. (1997) DNA Cell Biol. 16:131 1-1319. (SCI) (NSC84-2331-B-1 82-070-M06, NSC85-2331-B-1 82-062-M06)
  34. Shui-nin Li, Yu-sun Chang and Shih-tung Liu. Effect of a 10-amino acid deletion on the oncogenicity of latent membrane protein 1 of Epstein-Barr virus. (1996) Oncogene 12:2129-2135. (SCI) (NSC83-0412-B1 82-030)
  35. Shih-tung Liu, Shui-nin Li, Ding-cheng Wang, Shu-fang Chang, Su-chunag Chiang, Wei-chuang Ho, Yu-sun Chang and Shiow-suey Lai. Rapid detection of hog cholera virus in tissues by the polymerase chain reaction. (1991) J. Virol. Methods. 35:227- 236. (SCI)
  36. Ying-chieh Tsai, Tzu-yu Yang, Shiow-wen Chen, Shui-nin Li and Yng-jiin Wang.High-yield extraction and purification of glutathione reductase from Baker's yeast. (1991) Preparative Biochem. 21:175-185. (SCI) (NSC76-0412-B010-19)
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