Associate Professor Cheng, Chih-Mei
PhD, Kaohsiung Medical University , R.O.C.
Courses Offered:
Cell Culture and Tissue Engineering, Laboratory of Cell Culture and Tiassue Engineering
Biochemistry, Cell Biology, Molecular Biology
Academic Interests:
Mechanisms involved in GERD associated asthma
Mechanisms involved in enviromental disrupting chmical and allergic asthma

  1. Emily J. Bian , Ching-Wen Chen , Chih-Mei Cheng , Chia-Yi Kuan and Yu-Yo Sun (2023). Impaired post-stroke collateral circulation in sickle cell anemia mice. Frontiers in Neurology, DOI 10.3389/fneur.2023.1215876.
  2. Hsiang-Han Su , Chih-Mei Cheng ,, Yung-Ning Yang , Yu-Wei Chang , Chia-Yang Li , Shin-Ting Wu1, Chia-Chi Lin , Hsin-En Wu1 and Jau-Ling Suen (2023). Acrylamide, an air pollutant, enhances allergen-induced eosinophilic lung inflammation via group 2 innate lymphoid cells. Mucosal Immunology. (SCI).
  3. Padhmavathi Selvama, Chih-Mei Cheng, Hans-Uwe Dahmsb, Vinoth Kumar Ponnusamy , Yu-Yo Sun (2022, Oct). AhR mediated activation of proinflammatory response of RAW 264.7 cells modulate the epithelial-mesenchymal transition . Toxic, (SCI). nstc 108-2635-B-037-003. 本人為通訊作者.
  4. Chen CM, Suen JL, Su HH, Hsieh CC , Cheng,Chih Mei (2020, Sep). Stimulatory Effect of Gastroesophageal Reflux Disease (GERD) on Pulmonary Fibroblast Differentiation. Digestive and Liver Disease, 52( 9) : P 988-994. MOST 99-2320-B-037-027-MY3. 本人為通訊作者.
  5. Chen C M ,Cheng A C, Chou W, Selvam P, Cheng CM (2020, Jun). Outcome of bundle care in acute respiratory failure patients. Nursing in Critical Care,, DOI:10.1111/nicc.12530 14/123,. 本人為通訊作者.
  6. Peng, SY., Hsiao,CC., Lan, TH.,Ching-Yui Yen,CY., Farooqi ,AA., Cheng,CM., Tang,JY., Tzu-Jung Yu,TJ.,Chiu,CC., Chang,HW (2020, Jan). Pomegranate extract inhibits migration and invasion of oral cancer HSC-3 cells by downregulating MMP-2/9 and EMT. Environmental Toxicology , 35:673–682..
  7. Hsu, S. K., Chiu, C. C., Dahms, H. U., Chou, C. K., Cheng, C. M., Chang, W. T.,Cheng, K. C., Wang, H. D., and Lin, I. L. (2019). Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells. Int J Mol Sci, 2019, 20:2518;.
  8. Tseng CH , Tung CW, Peng SI, Chen YL, Tzeng CC , Cheng CM, (2018). Pyrazolo[4,3-c]quinolines Derivatives as Potential Anti-Inflammatory Agents through Inhibiting of NO Production. Molecules.
  9. Hsiang-Han Su, Hsin-Ting Lin, Jau-Ling Suen, Chau Chyun Sheu, Kazunari K.Yokoyama1, Shau- Ku Huang *, and Chih Mei Cheng (2016, Sep). Aryl hydrocarbon receptor–ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism. Toxicology, 370:116-126. (SCI). 
  10. Hsiang-Han Su, Hsin-Ting Lin, Jau-Ling Suen, Chau Chyun Sheu, Kazunari K.Yokoyama1, Shau- Ku Huang *, and Chih Mei Cheng (2016, Sep). Aryl hydrocarbon receptor–ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism. Toxicology, 370:116-126.
  11. Chih-Hua Tseng , Cherng-Chyi Tzeng , Chih-Yao Hsu , Chih-Mei Cheng ,ChiaNing Yang , Yeh-Long Chen (2015, Apr). Discovery of 3- phenylquinolinylchalcone derivatives as potent and selective anticancer agents against breast cancers. European Journal of Medicinal Chemistry, 97:306-319.
  12. Tseng, C.-H., Chen, Y.-L., Hsu, C.-Y., Chen, T.-C., Cheng, C.-M., Tso, H.-C., Lu, Y.-J., and Tzeng, C.-C (2013). Synthesis and antiproliferative evaluation of 3- phenylquinolinylchalcone derivatives against non-small cell lung cancers and breast cancers. European Journal of Medicinal Chemistry. European Journal of Medicinal Chemistry, 59:274-282. (SCI).
  13. Tseng, C.-H., Cheng, C.-M., Tzeng, C.-C., Peng, S.-I., Yang, C.-L., and Chen, Y.- L. (2013). Synthesis and Anti-inflammatory Evaluations of β-Lapachone Derivatives.. Bioorganic & Medicinal Chemistry, 21, 523-531. (SCI).
  14. Shih, PK, Chen, YC, Huang,YC Yu-Tang Chang,YT, Jian-Xun, Chen,JX, Cheng,CM (2011, Mar). Pretreatment of Vitamin D3 Ameliorates Lung and Muscle Injury Induced by. Journal of Surgical Research. (SCI).
  15. Chih-Hua Tseng,a,d Yeh-Long Chen,a,d Kuin-Yu Chung,a Chi-Huei Wang,b Shin-I Peng,a Chih-Mei (2011, Feb). Synthesis and antiproliferative evaluation of 2,3-diarylquinoline. Organic & Biomolecular Chemistry. (SCI).
  16. Tseng, C.H., Chen, Y.L., Chung, K.Y., Wang, C.H., Peng, S.I., Cheng, C.M., and Tzeng, C.C. (2011) Synthesis and antiproliferative evaluation of 2,3- diarylquinoline derivatives. Org Biomol Chem, 9, 3205-3216. (SCI).
  17. Tseng, C.H., Chen, Y.L., Yang, S.H., Peng, S.I., Cheng, C.M., Han, C.H., Lin, S.R., and Tzeng, C.C. (2011). Synthesis and antiproliferative evaluation of certain iminonaphtho[2,3-b]furan derivatives.. Bioorg Med Chem, 18, 5172- 5182.. (SCI).
  18. Tseng, C.H., Tzeng, C.C., Chung, K.Y., Kao, C.L., Hsu, C.Y., Cheng, C.M., Huang, K.S., and Chen, Y.L. (2011). Synthesis and antiproliferative evaluation of 6-aryl-11-iminoindeno[1,2-c]quinoline derivatives. Bioorg Med Chem, 19, 7653-7663. (SCI).
  19. Chiu, H.Y., Chen, C.W., Lin, H.T., Hsieh, C.C., Lin, S.S., and Cheng, C.M. (2011). Study of gastric fluid induced cytokine and chemokine expression in airway smooth muscle cells and airway remodeling. Cytokine, 56, 726-731. (SCI).
  20. Tseng, C.H., Tzeng, C.C., Shih, P.K., Yang, C.N., Chuang, Y.C., Peng, S.I., Lin, C.S., Wang, J.P., Cheng, C.M., and Chen, Y.L (2011). Identification of furo[3', 2':3,4]naphtho[1,2-d]imidazole derivatives as orally active and selective inhibitors of microsomal prostaglandin E(2) synthase-1 (mPGES-1). Molecular diversity. (SCI).
  21. Shih, P. K. Cheng, C. M. Li, H. P. Huang, M. F. Chiu, C. W. Chen, J. X. Chen, N. W. Chou, S. H.(2013)。Pretreatment with sildenafil alleviates early lung ischemia-reperfusion injury in a rat model, Journal of surgical research。Journal of surgical research,E77-E83。
  22. Cheng, CM , Hsieha, CC , Lin, CS Dai, ZK, Shih PK, Everettd, M ,Thomas,AParkerd,W ,Davisd, RD ,Lin,SS (2010, Feb). Macrophage activation by gastric fluid suggests MMP involvement in aspiration-induced lung disease. Immunobiology, 215, 173-181. (SCI).
  23. Tseng , CH, Lin CS, Shih PK, Tsao LT, Wang JP, Cheng CM,*, Tzeng CC, Chen YL,* (2009, Sep). Furo[30,20:3,4]naphtho[1,2-d]imidazole derivatives as potential inhibitors of inflammatory factors in sepsis,. Bioorganic & Medicinal Chemistry, 17:6773–6779. (SCI).
  24. Tseng CH , Chen YL, Chun KY, Cheng CM*, Wang CH ,Tzeng CC, (2009, Sep). Synthesis and antiproliferative evaluation of 6-arylindeno[1,2-c]quinoline derivatives,. Bioorganic & Medicinal Chemistry, 17 :7465–7476. (SCI).
  25. Lee, Y.H., Cheng, C.M., Chang, Y.F., Wang, T.Y., and Yuo, C.Y. (2007). Apoptin T108 phosphorylation is not required for its tumor-specific nuclear localization but partially affects its apoptotic activity. Biochem Biophys Res Commun 354, 391-395.
  26. Chang, Y.F., Cheng, C.M., Chang, L.K., Jong, Y.J., and Yuo, C.Y. (2006). The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. Biochem Biophys Res Commun 342, 1022-1026.
  27. Cheng, C.M., Huang, S.P., Chang, Y.F., Chung, W.Y., and Yuo, C.Y. (2003). The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1. Biochem Biophys Res Commun 305, 359-364.
  28. C.M., Chang, Y.F., and Yuo, C.Y. (1997). Sequence of a human E2F-4 pseudogene with shortened AGC trinucleotide repeats. Kaohsiung J Med Sci 13, 448-452.

Symposium publication:

  1. Cheng, C.-M, Chen, D.-Y, Lin, Y.-M., Yuo, C.-Y. 1999. Cloning and characterization of the Apoptin-associated proteins. The 14th Joint Ann. Conf. Biomed. Sci., Taipei, Taiwan.
  2. Cheng, C.-M, Lien, W.-H., Lee, S.-Y., and Yuo, C.-Y. 2000. APAP1, an apoptin-associated protein, causes cell death. The 15th Joint Ann. Conf. Biomed. SCI., Taipei, Taiwan.
  3. Cheng, C.-M., Chung, W.-Y., and Yuo, C.-Y. 2003. Apoptin induces apoptosis probably through the death effector domain-mediated pathway. The 11th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan.
  4. Cheng, C-M1., Chien, MS., Chen SY., Lee SJ., Yuo CY., 2005, Study and characterization of APAP1/DEDAF in zebrafish developmentThe 13th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan.
  5. An anti-inflammatory study of Ovatodiolide in Raw264.7 cells , Chen Y J, Hsieh C C, Chen Y L, Cheng C-M, 2007,高雄醫學大學生命科學院 第一屆論文競試
  6. Hsieh, C C ., Lin, CS., Cheng,C-M., Pro-Inflammatory Study of Gastric Fluid Acid in Raw 264.7 cells , 2007, 47th Annual meeting of American Society for Cell Biology
  7. Chiu, HY, Cheng, CW, Lin, CS , Hsieh, CC, Lin,SS, Parker,W, Cheng, CM, 2009, Studies of Gastric Fluid in Rat Airway Smooth Muscle Cells, 97年度彰高輔合作研究成果發表會
  8. Lee,SM, Ching T, Schneider,F, Holzknecht,Z ,Thomas,A Su,KY, Parker,W Davis,RD, Cheng,CM ,. Lin.SS, The Role of Macrophages in the Response to Aspirated Gastric Fluid in Lung Allografts , American J of Transplantation 9: 393-393 Suppl. 2 , 2009, Transplantation , IF 6.5, 1/21
  9. Synthesis and Anti-inflammatory Evaluation of Furo[3',2':3,4]naphtho[1,2-d]imidazole Derivatives Shin-I Peng, Chih-Hua Tseng, Chang-Sheng Lin, Pin-Keng Shih, Chih-Mei Cheng, Yeh-Long Chen and Cherng-Chyi Tzeng 2010,高雄醫學大學生命科學院論文競試
  10. Pro inflammatory role of gastric fluid in primary culture of rat airway smooth muscle cells ,Chiu, HY, Chiu CW, Chen, CW, Hsieh, CC, Lin,SS, Parker,W, Cheng, CM, 2011 Keystone Symposia Conference, Immunity in the Respiratory Tract: Challenges of the Lung Environmen
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