Associate Professor Tan, Mian-Shin



Ph.D Kaohsiung Medical University

Courses Offered:

General Biology, Genetics Specialty: Genetics, molecular and cellular biology

Academic Interests:

Regulatory mechanisms of signal molecules in diabetes and cardiovascular diseases


  1. Dai ZK, Wu BN, Chen IC, Chai CY, Wu JR, Chou SH, Yeh JL, Chen IJ, Tan MS.Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil. Pediatr Pulmonol. 2010 Aug 17. [Epub ahead of print] DOI: 10.1002/ppul.21323 (Impact Factor: 1.816, Rank:PEDIATRIC  32/94 = 0.34)

  2. Dai ZK, Hsieh CC, Chai CY, Wu JR, Jeng AY, Chou SH, Wu BN, Yeh JL, Chen IJ, Tan MS.Protective effects of a dual endothelin converting enzyme/neutral endopeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat. Pediatr Pulmonol. 2010 Nov;45(11):1076-85  (Impact Factor: 1.816, Rank:PEDIATRIC  32/94 = 0.34)

  3. Dai ZK, Tan MS, Chai CY, Chou SH, Lin PC, Yeh JL, Jeng AY, Chang CI, ChenIJ, Wu JR. Effects of sildenafil on pulmonary hypertension and levels of ET-1, eNOS, and cGMP in aorta-banded rats. Experimental Biology and Medicine (Maywood). 2006, 231(6):942-7. (Impact factor:2.851;Ranking:18/72=25%)
  4. Tan MS, Chai CY, Wu JR, Yeh JL, Chen IJ, Kwan AL, Jeng AY, Yang HY, Lee MH, Dai ZK. Differential change in expression of pulmonary ET-1 and eNOS in rats after chronic left ventricular pressure overload. Experimental Biology and Medicine (Maywood). 2006, 231(6):948-53. (Impact factor:2.851;Ranking:18/72=25%)
  5.  Chou SH, Chai CY, Wu JR, Tan MS, Chiu CC, Chen IJ, Jeng AY, Chang CI, Kwan AL, Dai ZK. The effects of debanding on the lung expression of ET-1, eNOS, and cGMP in rats with left ventricular pressure overload.Experimental Biology and Medicine (Maywood). 2006, 231(6):954-9. (Impact factor:2.851;Ranking:18/72=25%)
  6.  Dai ZK, Tan MS, Chai CY, Chen IJ, Jeng AY, Kwan AL, Howng SL, Wu JR. Different Changes in Endothelin-1 and Endothelial Nitric Oxide Synthase Gene Expression in Rats with a Chronic high Pulmonary Flow. J Cardiovasc Pharmacol/TM 2004;44(1):S341-345
  7.  HC Chen, HS Chuang, MC Hsieh, MS Tan, JY Guh, YT Hsu, SJ Shin. Effects of Angiotensin Ⅱ on the Proliferation and Fibronectin Production of Glomerular Mesangial Cells. Acta Nephrologica 2004;18(2):57-61
  8. HS Chuang, HC Chen, MC Hsieh, MS Tan, JY Guh, YT Hsu, SJ Shin. Effect of oendothelin-1 receptor antagonists on cellular proliferation and fibronectin mRNA expression of cultured rat mesangial cells. Acta Nephrologica 2004;18(1):1-7
  9. Dai ZK, Tan MS, Chai CY, Yeh JL, Chou SH, Chiu CC, Jeng AY, Chen IJ, Wu JR. Upregulation of Endothelial Nitric Oxide Synthase and Endothelin-1 in Pulmonary Hypertension Secondary to Heart Failure in Aorta-Banded Rats. Pediatric Pulmonology 2004;37:249-256
  10. Tan MS, Chang SY, Chang DM, Tsai JCR, Lee YJ. Association of resistin gene 3’UTR +62G>A polymorphism with type 2 diabetes and hypertension in a Chinese population. J Lab Clin Med 88 (3):1258-1263, 2003.
  11. Dai ZK, Tan MS, Chai CY, Chen IJ, Jeng AY, Wu JR. Effects of increased pulmonary flow on the expression of endothelial nitric oxide synthase and endothelin-1 in the rat. Clin Sci (Lond) 103 Suppl 48:289S-293S, 2002.
  12. Chen HC, Tan MS, Guh JY, Tsai JH, Lai YL. Native and oxidized low-density lipoproteins enhance superoxide production from diabetic rat glomeruli. Kidney Blood Press Res 23(2):133-137, 2000. Tan M-S, Lee Y-J, Shin S-J, Tsai J-H. Oxidized low-density lipoprotein stimulates endothelin-1 release and mRNA expression from rat mesangial cells. J Lab Clin Med 129:224-230, 1997.
  13. Shin S-J, Lee Y-J, Tan M-S, Tsai J-H. Increase ANP synthesis in the kidney of diabetic rats. Kidney Int 51:1100-1105, 1997. Lee Y-J, Shin S-J, Tan M-S, Hsieh T-J, Tsai J-H. Increased renal atrial natriuretic peptide synthesis in rats with deoxycorticosterone acetate-salt treatment. Am J Physiol 271:F779-F789, 1996.
  14. Lee Y-J, Shin S-J, Lin S-R, Tan M-S, Tsai J-H. Increased expression of heparin binding-epidermal growth factor like growth factor mRNA in the kidney of streptozotocin induced diabetic rats. Biochem Biophys Res Commun 207:216-222, 1995.
  15. Shin S-J, Lee Y-J, Lin S-R, Tan M-S, Lai Y-H, Tsai J-H. Decrease of renal endothelin-1 content and gene expression in diabetic rats with moderate hyperglycemia. Nephron 70:486-493, 1995.
  16. Tan M-S, Lee Y-J, Shin S-J, Tsai T-H. Regulation of heparin binding epidermal growth factor like growth factor gene expressin by LDL and oxidized LDL in rat mesangial cells. Biochem Biophys Res Commun 202:1001-1008, 1994.
  17. Tan M-S, Tsai J-C, Lee Y-J, Chen H-C, Shin S-J, Lai Y-H, Perrella MA, Bianchi C, Higashiyama S, Endege W, Lee M-E, Tsai J-H. Induction of heparin binding epidermal growth factor like growth factor mRNA by protein kinase C activators. Kidney Int 46:690-695, 1994.
  18. Kuo T-T, Tan M-S, Su M-T, Yang M-K. Complete nucleotide sequence of filamentous phage Cf1c from Xanthomonas campestris pv. citri. Nucleic Acids Res 19 (9):2498, 1991. 
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