Education:
Ph.D., Yale University, U.S.A.

Academic Interests:

Studies on the regulation of SMN2 exon 7 alternative splicing

Analysis of the genes regulated by Nmi and the role of Nmi in cancer cell metastasis

Publications:

1. Liu, T.-Y., Yuo, C.-Y., Kao, C.-H., Tseng, C.-N., Jong, Y.-J., Chang, J.-G., Wu, S.-M., and Chang, Y.-F. 2011. Hydrogen peroxide decreases the survival rate of HeLa cells with stable knockdown of survival motor neuron protein. Kaohsiung J. Med. Sci. 27, 102-107.
2. Chen, Y.-C., Yuo, C.-Y., Yang, W.-K., Jong, Y.-J., Lin, H.-H., Chang, Y.-S., and Chang, J.-G. 2008. Extracellular pH change modulates the exon 7 splicing in SMN2 mRNA. Mol. Cell. Neurosci. 39, 268-272.
3. Wang, C.-C., Chang, J.-G., Ferrance, J., Chen, H.-Y., Yuo, C.-Y., Chang, Y.-F., Jong, Y.-J., Wu, S.-M., and Yeh, C.-H. 2008. Quantification ofSMN1 and SMN2 genes by capillary electrophoresis for diagnosis of spinal muscular atrophy. Electrophoresis 29, 2904-11.
4. Liang, W.-C.^#, Yuo, C.-Y.^#, Chang, J.-G., Chen, Y.-C., Wang, H.-Y., Ju, Y.-H., Chiou, S.-S., and Jong, Y.-J. 2008. The effect of hydroxyurea in spinal muscular atrophy cells and patients. J. Neurol. Sci. 268, 87-94. (^#equal contribution)
5. Yuo, C.-Y., Lin, H.-H., Chang, Y.-S., Yang, W.-K., and Chang, J.-G. 2008. 5-(N-ethyl-N-isopropyl)-amiloride enhances SMN2 exon 7 inclusion and protein expression in spinal muscular atrophy cells. Ann. Neurol. 63, 26-34.
6. Lee, Y.-H., Cheng, C.-M., Chang, Y.-F., Wang, T.-Y., and Yuo, C.-Y.* 2007. Apoptin T108 phosphorylation is not required for its tumor-specific nuclear localization but partially affects its apoptotic activity. Biochem. Biophys. Res. Commun. 354, 391-395.
7. Lin, Y.-C., Murakami, T., Hayashi, Y.K., Nishino, I., Nonaka, I. , Yuo, C.-Y., and Jong, Y.-J. 2007. A novel FKRP gene mutation in a Taiwanese patient with limb-girdle muscular dystrophy 2I. Brain Dev. 29, 234-238.
8. Liang, W.-C., Yuo, C.-Y., Liu, C.-Y., Lee, C.-S., Goto, K., Hayashi, Y.K., and Jong, Y.-J. 2007. A novel LMNA mutation in a Taiwanese family with autosomal dominant Emery-Dreifuss muscular dystrophy. J. Formos. Med. Assoc. 106, S27-S31.
9. Chang, Y.-F., Cheng, C.-M., Chang, L.-K., Jong, Y.-J., and Yuo, C.-Y.* 2006. The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. Biochem. Biophys. Res. Commun. 342, 1022-1026.
10. Cheng, C.-M., Huang,S.-p., Chang, Y.-F., Chung, W.-Y., and Yuo, C.-Y.* 2003. The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin interacting protein 1. Biochem. Biophys. Res. Commun. 305, 359-364.