Courses offered

Courses offered:

Molecular Biotechnology, Molecular Oncology, Principles and Technologies of Cell Biology、Special Topics on Cell Molecular Biology, General Biology (Including Laboratory)

Specialty & Research Interests

Specialty：

Tumor Biology, Bacterial Pathogenesis, Molecular Medicine, Biomarkers, Therapeutic targets

Research Interests：

Screen potential biomarkers for various tumors or pathogenic bacteria to: (1) explore their molecular mechanisms; (2) confirm their applications in diagnosis, prognosis and targeted therapy.

Patents:

1. METHOD FOR THE TREATMENT OF ATG4-RELATED DISORDERS-美國US20190183860.

Lee-Wei Yang, Chih-Wen Shu, Pei-Feng Liu, Kun-Lin Tsai.

Honors

Teaching

• Outstanding Course Assessment- Kaohsiung Medical University (112 School year)

• Outstanding Course Assessment- Kaohsiung Medical University (111 School year)

• Outstanding Course Assessment- Kaohsiung Medical University (110 School year)

• Outstanding Teacher Teaching Evaluation- Kaohsiung Medical University (108 School year)

• Outstanding Course Assessment- Kaohsiung Medical University (108 School year)

Research

• Faculty Research Paper Award- Kaohsiung Medical University (112 School year)

• Faculty Research Paper Award- Kaohsiung Medical University (111 School year)

• Outstanding Research Faculty- Kaohsiung Medical University (110 School year)

• Faculty Research Paper Award- Kaohsiung Medical University (110 School year)

• Faculty Research Paper Award- Kaohsiung Medical University (109 School year)

• Outstanding Research Faculty- Kaohsiung Medical University (108 School year)

• Faculty Research Paper Award- Kaohsiung Medical University (108 School year)

• Young research scholarship- Yen Tjing Ling Medical Foundation (2018)

Service/counseling

• Instructing undergraduate student for oral presentation (the excellent award) - Kaohsiung Medical University (114 School year)

• Instructing undergraduate student to report excellent results in their summer special research - Kaohsiung Medical University (113 School year)

• Instructing undergraduate student for oral presentation (the best oral paper award)- the College of Life Science at Kaohsiung Medical University (113 School year)

• Instructing undergraduate student for poster presentation (the high distinction award)- the College of Life Science at Kaohsiung Medical University (113 School year)

• Instructing undergraduate student for poster presentation (the excellent award)- the College of Life Science at Kaohsiung Medical University (113 School year)

• Instructing undergraduate student for poster presentation (the excellent award)- the College of Life Science at Kaohsiung Medical University (112 School year)

• Instructing undergraduate student for poster presentation (the honorable mention award)- the College of Life Science at Kaohsiung Medical University (112 School year)

• Instructing undergraduate student to report excellent results in their summer special research- Kaohsiung Medical University (112 School year)

• Outstanding Student Mentor (College of Life Science)- Kaohsiung Medical University (111 School year)

• Instructing summer undergraduate student for poster presentation award (the excellent award)- Kaohsiung Medical University (111 School year)

• Instructing undergraduate student for poster presentation award (the excellent award)- the College of Life Science at Kaohsiung Medical University (111 School year)

• Instructing undergraduate student for poster presentation award (the honorable mention award)- the College of Life Science at Kaohsiung Medical University (111 School year)

• Instructing undergraduate student for the research grant from National Science and Technology Council-Kaohsiung Medical University (110 School year)

• Outstanding Counsellor Mentor- Kaohsiung Medical University (110 School year)

• Instructing summer undergraduate student for poster presentation award (the high distinction award)- Kaohsiung Medical University (110 School year)

• Instructing undergraduate student for poster presentation award (the honorable mention award)- the College of Life Science at Kaohsiung Medical University (110 School year)

• Instructing graduate student for poster presentation award (the third place)- the College of Life Sciences at Kaohsiung Medical University (109 School year)

• Instructing undergraduate student for poster presentation award (the honorable mention award)- the College of Life Sciences at Kaohsiung Medical University (109 School year)

• Instructing summer undergraduate student for poster presentation award (the excellent award)- Kaohsiung Medical University (109 School year)

• Outstanding Student Mentor (College of Life Science)- Kaohsiung Medical University (108 School year)

Publications

Publications: (^#: first author; *: corresponding author)

2025

1.    CW Shu, CH Chang, HH Wang, PF Liu^* (co-corresponding author), YF Chang^*(2025) Transmembrane Proteins (TMEMs) in Cancer: Insights from Mechanism to Clinical Impact. Open Biology (Accepted, IF:3.6, 129/319, BIOCHEMISTRY & MOLECULAR BIOLOGY)

2.    CW Shu, CF Chen, CC Chang, CH Lee, HH Tseng, KF Hu, YH Chou, CL Chen, WC Wang^*, PF Liu^* (2025) The reciprocal regulation between TNF-α and autophagy for oral squamous cell carcinoma progression. Journal of Oral Pathology & Medicine (Accepted, IF: 2.3, 53/162, DENTISTRY, ORAL, SURGERY &MEDICINE)

3.    KF Hu, JL Yeh, YC Lin, PF Liu, YH Chou^*, CJ Tseng^* (2025) The correlation between body mass index and the effectiveness of non-surgical periodontal treatment in Taiwan population. Clinical Oral Investigations 29(12):596. (IF: 3.1, 30/162, DENTISTRY, ORAL, SURGERY &MEDICINE)

4.    PF Liu^{# *}, SW Yang^#, WH Yang, SF Huang, CY Tsai, CJ Hsu, HH Tseng, CH Lee, CW Shu^* (2025) Autophagy Protease ATG4D Facilitates Proliferation and Malignancy of Osteosarcoma Cells. FABES Journal 39(17):e70990. (IF: 4.2, 17/107 (<20%), Biology)

5.    Liu HP, Tai SB, Jiang JL, Tey SF, Liu PF, Lin MW, Wu SC, Chen YC, Chen CL^* (2025) Epac (RAPGEF3) promotes betaglycan expression to mediate ciprofloxacin-induced suppression of cancer cell migration and metastasis: Mechanistic insights and drug repurposing potential. Biomedicine & Pharmacotherapy 189:118261. (IF: 7.5, 19/352 (<10%), PHARMACOLOGY & PHARMACY)

6.    Hu KF, Chou YH, Lan CC, Ho PS, Liu PF^* (co-corresponding author), Tseng CJ^* (2025) Greater bone regeneration required for implants following periodontal extraction: a retrospective cross-sectional study. BMC Oral Health 18;25(1):586. (IF: 3.1, 30/162(<20%), DENTISTRY, ORAL SURGERY & MEDICINE)

7.    YC Tseng^#, PF Liu^# (co-first author), YR Chen, WH Yang, CC Chang, HW Chang, CH Lee, YG Goan^*, CW Shu^*(2025) Elevated neuregulin-1 expression modulates tumor malignancy and autophagy in esophageal squamous cell carcinoma. International Journal of Molecular Medicine 55(4):62. (IF:5.8, 39/195 (20%), MEDICINE, RESEARCH & EXPERIMENTAL)

8.    HL Chou^#, IL Lin^#, YT Chen, WT Chang, A Yu, WC Chen, CY Wu, SJ Chiou, CW Shu, CC Chiu^*, PF Liu^*(2025) Aniline TFPA enhances camptothecin-induced anti-NSCLC by modulating oxidative stress and impairing autophagy. Cancer Cell International 25:81. (IF: 6.0, 55/326 (<20%), ONCOLOGY)

9.    JR Weng^#, CW Shu^#, CC Chang^#, YC Wu, HC Yang, CH Lee, HU Dahms, WY Lin, CL Chen, PF Liu^* (2025) Aglaia elliptifolia leaf extract inhibits autophagy-related 4B protease and suppresses malignancies of colorectal cancer cells. Environmental Toxicology 40 (4):549–562. (IF: 3.2, 42/131, WATER RESOURCES)

10. KF Hu^#, CW Shu^#, CF Chen, CH Lee, HC Kung, YH Chou, CL Chen, PF Liu^* (2025) Regulation of exosomal miR-320d/FAM49B axis by guanylate binding protein 5 promotes cell growth and tumor progression in oral squamous cell carcinoma. Journal of Oral Pathology & Medicine 54(5):298-311. (IF: 2.3, 53/162, DENTISTRY, ORAL, SURGERY &MEDICINE)

11. M Jadhao, SK Hsu, D Deshmukh, PF Liu, SF Weng, YF Chen, CY Lee, CY Wang, EM Tsai, LF Wang^*, CC Chiu^*(2025) Prolonged DEHP exposure enhances the stemness and metastatic potential of TNBC in an MSI2-dependent manner. International Journal of Biological Sciences 21(4):1705-172. (IF: 10, 26/319 (<10%), BIOCHEMISTRY & MOLECULAR BIOLOGY)

12. Wang YC, Tai SB, Yang JL, Liu PF, Sung PJ, Su JH, Chen CL (2025). Analysis of Cembrane-Type Diterpenoids from Cultured Soft Coral Sclerophytum flexibile for Inhibition of TGF-β-Induced IL-6 Secretion in Inflammation-Associated Cancer. International Journal of Molecular Sciences. 26(23):11280. (IF: 4.9, 72/319, BIOCHEMISTRY & MOLECULAR BIOLOGY)

13. YH Chou, WL Hsiao, CJ Chen, YC Lin, PF Liu, KF Hu^*, Cheng CW^* (2025). Association between prosthesis contour and peri-implantitis in patients compliant with supportive periodontal therapy: A retrospective cohort study. Journal of Prosthodontic Research 69(1):68-75. (IF:3.4, 25/162 (<20%), DENTISTRY, ORAL SURGERY & MEDICINE)

2024

14. CF Chen, CM Chen^*, WC Huang, SH Liu, LL Wang, PF Liu, PH Chen^* (2024). The use of customized 3D-printed mandibular prostheses with pressure-reducing device: a clinical trial. Head & Neck 46:1614–1624. (IF: 2.2, 15/67, OTORHINOLARYNGOLOGY)

15. CF Chen, WC Huang, SH Liu, LL Wang, PF Liu, Chen PH, Chen CM^* (2024). Use of customized 3-dimensional printed mandibular prostheses with a dental implant pressure-reducing device in mandibular body defect: a finite element study performing multiresponse surface methodology. Journal of Dental Sciences 19(1):502-514. (IF: 3.1, 30/162 (<20%), DENTISTRY, ORAL SURGERY & MEDICINE)

2023

16. KF Hu^#, CW Shu^#, CH Lee, CJ Tseng, YH Chou, PF Liu^* (2023). Comparative clinical significance and biological roles of PFKFB family members in oral squamous cell carcinoma. Cancer Cell International 23(1):257. (IF: 6.0, 55/326, ONCOLOGY)

17. JL Yang^#, WL Lin^#, SB Tai, YS Ciou, CL, Chung, JJ Chen, PF Liu, MW Lin, CL Chen^* (2023) Suppression of TGFβ-induced interleukin-6 secretion by sinulariolide from soft corals through attenuation of the p38–NF-κB pathway in carcinoma cells. International Journal of Molecular Sciences. 24 (14), 11656. (IF: 4.9, 72/319, BIOCHEMISTRY & MOLECULAR BIOLOGY)

18. YH Chou^#, YJ Chen^#, CP Pan, WH Yen, PF Liu, IJ Feng, YC Lin^*, KF Hu^*(2023). Prevalence of peri-implantitis after alveolar ridge preservation at periodontitis and nonperiodontitis. Clinical Implant Dentistry and Related Research 25(6):1000-1007. (IF: 4.0, 14/162 (<10%), DENTISTRY, ORAL SURGERY & MEDICINE)

19. SW Lin, KF Hu^*, YC Lin, PF Liu, YH Chou^* (2023) Changes in alveolar bone width around maxillary implants, as determined through cone beam computed tomography based on bony landmarks: a preliminary study. Clinical Implant Dentistry and Related Research. 25(5):861-870. (IF: 4.0, 14/162 (<10%), DENTISTRY, ORAL SURGERY & MEDICINE)

20. YF Chang^#, HH Wang^#, CW Shu, WL Tsai, CH Lee, CL Chen, PF Liu^* (2023) TMEM211 promotes tumor progression and metastasis in colon cancer. Current Issues in Molecular Biology 45(6), 4529-4543. (IF: 3.0, 169/319, BIOCHEMISTRY & MOLECULAR BIOLOGY)

21. PF Liu and YF Chang^* (2023) The controversial roles of areca nut: medicine or toxin? International Journal of Molecular Sciences 24(10), 8996. (IF: 4.9, 72/319, BIOCHEMISTRY & MOLECULAR BIOLOGY)

22. CC Tseng^#, CC Hung^#, CW Shu, CH Lee, CF Chen, MS Kuo, YY Kao, CL Chen, LP Ger, PF Liu^*(2023) The clinical and biological effects of receptor expression-enhancing protein 6 in tongue squamous cell carcinoma. Biomedicines 11(5), 1270. (IF: 3.9, 88/352, PHARMACOLOGY & PHARMACY)

23. WH Hu^#, TT Liu^#, PF Liu, P Morgan, IL Lin, WL Tsai, YY Cheng, AT Hsieh, TH Hu, CW Shu^* (2023) ATG4B and pS383/392-ATG4B serve as potential biomarkers and therapeutic targets of colorectal cancer. Cancer Cell International 23(1):63. (IF: 6.0, 55/326 (<20%), ONCOLOGY)

2022

24. PF Liu^#, CF Chen^#, LP Ger, WL Tsai, HH Tseng, CH Lee, WH Yang, CW Shu* (2022) MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma. Journal of Cellular Physiology 237(11):4275-4291. (IF: 4.0, 14/87(<20%), PHYSIOLOGY)

25. PF Liu^#, AA Farooqie^#, SY Peng, TJ Yu, HU Dahms, C H Lee, JY Tang, SC Wang, CW Shu^*, HW Chang^* (2022) Regulatory effects of noncoding RNAs on the interplay of oxidative stress and autophagy in cancer malignancy and therapy. Seminars in Cancer Biology 83:269-282. (IF: 15.7, 18/326 (<10%), ONCOLOGY)

26. YH Chou, YC Lin, MH Lee, YT Huang, PF Liu, CL Huang, KF Hu^* (2022) Highly educated patients have lower dental compliance during the covid-19 pandemic: an observational study. BMC Oral Health 22(1):284. (IF: 3.1, 30/162(<20%), DENTISTRY, ORAL SURGERY & MEDICINE)

27. WL Tsai^*, JS Cheng, PF Liu, TH Chang, WC Sun, WC Chen, CW Shu^* (2022) Sofosbuvir induces gene expression for promoting cell proliferation and migration of hepatocellular carcinoma cells. Aging-US 14(14):5710-5726. (2023 IF: 3.9, 24/74, GERIATRICS & GERONTOLOGY)

28. KC Chang, PF Liu, CH Chang, YC Lin, YJ Chen, CW Shu^* (2022) The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases. Cell and Bioscience 12(1):1. (IF: 6.2, 50/319 (<20%), BIOCHEMISTRY & MOLECULAR BIOLOGY)

2021

29. PF Liu, CW Shu, CH Lee, HC Sie, HH Liou, JT Cheng, LP Ger, CL Chen, CC Chen^*, CF Chen^* (2021) Clinical significance and the role of guanylate-binding protein 5 in oral squamous cell carcinoma. Cancers (Basel) 13(16): 4043. (IF: 4.4, 85/326, ONCOLOGY)

30. PF Liu, CW Shu, HC Yang, CH Lee, HH Liou, LP Ger, YD Tony Tzeng^*, WC Wang^* (2021) Combined Evaluation of MAP1LC3B and SQSTM1 for biological and clinical significance in ductal carcinoma of breast cancer. Biomedicines 9(11):1514. (IF: 3.9, 88/352, PHARMACOLOGY & PHARMACY)

31. YK Tseng, CF Chen, CW Shu, CH Lee, YT Chou, YJ Li, HH Liou, JT Cheng, CL Chen, LP Ger, PF Liu^* (2021) Effect of EGFR on SQSTM1 expression in malignancy and tumor progression of oral squamous cell carcinoma. International Journal of Molecular Sciences 22(22):12226. (IF: 4.9, 72/319, BIOCHEMISTRY & MOLECULAR BIOLOGY)

32. JT Cheng^#, PF Liu^# (co-first author), HC Yang, SJ Huang, M Griffithg, P Morgang, CW Shu^* (2021) Tumor susceptibility gene 101 facilitates rapamycin-induced autophagic flux in neuron cells. Biomedicine & Pharmacotherapy 134:111106. (IF: 7.5, 19/352 (<10%), PHARMACOLOGY & PHARMACY)

33. CC Chang^#, CC Chiu^#, PF Liu, CH Wu, YC Tseng, CH Lee, CW Shu^* (2021) Kinome-wide siRNA screening identifies DYRK1B as a potential therapeutic target for triple-negative breast cancer cell. Cancers 13(22):5779. (IF: 4.4, 85/326, ONCOLOGY)

34. WH Hu^#, WC Yang^#, PF Liu, TT Liu, P Morgan, WL Tsai, HW Pan, CH Lee CW Shu^* (2021) Clinicopathological Association of autophagy related 5 protein with prognosis of colorectal cancer. Diagnostics 11(5):782. (IF: 3.3, 57/332(<20%), MEDICINE, GENERAL & INTERNAL)

35. CY Huang^#, JL Yang^#, JJ Chen^#, SB Tai, YH Yeh, PF Liu, MW Lin, CL Chung, CL Chen* (2021) Fluoroquinolones suppress TGF-β and PMA-Induced MMP-9 production in cancer cells: implications in repurposing quinolone antibiotics for cancer treatment. International Journal of Molecular Sciences 22(21):11602. (IF: 4.9, 72/319, BIOCHEMISTRY & MOLECULAR BIOLOGY)

36. KF Hu, SW Lin, YC Lin, JH Jeng, YT Huang, PF Liu, CJ Tseng^*, YH Chou^* (2021) Using cone-beam computed tomography to assess changes in alveolar bone width around dental implants at native and reconstructed bone sites: a retrospective cohort study. Journal of Personalized Medicine 11(10):1011. (2023 IF: 3.0, 59/329(<20%), MEDICINE, GENERAL & INTERNAL)

37. CW Shu^#, JR Weng^#, HW Chang, PF Liu, JJ Chen, CC Peng, JW Huang, WY Lin, CY Yen^* (2021) Tribulus Terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells. Environmental Toxicology 36(6):1173-1180. (IF: 3.2, 42/131, WATER RESOURCES)

38. CY Huang^#, CL Chung^#, TH Hu, JJ Chen, PF Liu, CL Chen^* (2021) Recent progress in TGF-β inhibitors for cancer therapy. Biomedicine & Pharmacotherapy 134:111046. (IF: 7.5, 19/352(<10%), PHARMACOLOGY & PHARMACY)

2020

39. PF Liu, CF Chen, CW Shu, HM Chang, CH Lee, HH Liou, LP Ger, CL Chen, BH Kang^* (2020) UBE2C is a potential biomarker for tumorigenesis and prognosis in tongue squamous cell carcinoma. Diagnostics 2020, 10(9):674. (IF: 3.3, 57/332(<20%), MEDICINE, GENERAL & INTERNAL)

40. PF Liu^*, HC Chen, CW Shu, HC Sie, CH Lee, HH Liou, JT Cheng, KW Tsai, LP Ger (2020) Guanylate-binding protein 6 is a novel biomarker for tumorigenesis and prognosis in tongue squamous cell carcinoma. Clinical Oral Investigations 24(8):2673-2682. (IF: 3.1, 30/162 (<20%), DENTISTRY, ORAL, SURGERY &MEDICINE)

41. HC Chen^#, YK Tseng^#, CW Shu, TY Fu, HH Liou, CH Huang, CC Chen, JS Wang, PC Wu, LP Ger, WC

  Hung, PF Liu^* (2020) Prognostic role of RECK in pathological outcome-dependent buccal mucosa squamous cell carcinoma. Oral Diseases 2020; 26(1):62-71. (IF: 2.9, 37/162, DENTISTRY, ORAL, SURGERY &MEDICINE)

42. BH Kang^#, CW Shu^#, JK Chao, CH Lee, TY Fu, HH Liou, LP Ger, PF Liu^* (2020) HSPD1 repressed  E-cadherin expression to promote cell invasion and migration for poor prognosis in oral squamous cell carcinoma. Scientific Reports 10(1):1829. (IF: 3.9, 25/135(<20%), MULTIDISCIPLINARY SCIENCES)

2019

43. PF Liu, HC Chen, JS Cheng, WL Tsai, HP Lee, SC Wang, WH Peng, CH Lee, LP Ger, CW Shu^* (2019)

   Association of ATG4B and phosphorylated ATG4B proteins with tumorigenesis and prognosis in oral squamous cell carcinoma. Cancers (Basel) 11(12): 1854. (IF: 4.4, 85/326, ONCOLOGY)

44. YG Goan, PF Liu, HW Chang, HC Chen, WC Chen, SM Kuo, CH Lee, CW Shu^* (2019) Kinome-wide screening with small interfering RNA identified polo-like kinase 1 as a key regulator of proliferation in oral cancer cells. Cancers (Basel) 11(8):1117. (IF: 4.4, 85/326, ONCOLOGY)

45. HC Chen^#, YK Tseng^#, CW Shu, TJ Weng, HH Liou, LM Yen, IC Hsieh, CC Wang, PC Wu, YL Shiue, TY Fu, KW Tsai, LP Ger^*, PF Liu^*(2019) Differential clinical significance of COL5A1 and COL5A2 in tongue squamous cell carcinoma. Journal of Oral Pathology & Medicine 48(6):468-476. (IF: 2.3, 53/162, DENTISTRY, ORAL, SURGERY &MEDICINE)

46. JS Cheng^#, WL Tsai^#, PF Liu^# (co-first author), YG Goan, CW Lin, HH Tseng, CH Lee, CW Shu^* (2019) The MAP3K7-mTOR axis promotes the proliferation and malignancy of hepatocellular carcinoma cells. Frontiers in Oncology 9:474. (IF: 3.3, 123/326, ONCOLOGY)

47. HW Chang^#, PF Liu^# (co-first author), WL Tsai, WH Hu, YC Hu, HC Yang, WY Lin, JR Weng, CW Shu^* (2019) Xanthium strumarium fruit extract inhibits ATG4B and diminishes the proliferation and metastatic characteristics of colorectal cancer cells. Toxins 11(6):313. (IF: 4.0, 26/106, TOXICOLOGY)

2018

48. HY Chang, YK Tseng, YC Chen, CW Shu, MI Lin, HH Liou, TY Fu, YC Lin, LP Ger, MH Yeh^*, PF Liu^*(2018) High snail expression predicts a poor prognosis in breast invasive ductal carcinoma patients with HER2/EGFR-positive subtypes. Surgical Oncology-Oxford 27(2):314-320. (IF: 2.4, 78/312, SURGERY)

49. PF Liu^#, KL Tsai^#, CJ Hsu^#, WL Tsai, JS Cheng, HW Chang, CW Shiau, YG Goan, HH Tseng, CH Wu, JC Reed, LW Yang, CW Shu^* (2018) Drug repurposing screening identifies tioconazole as an ATG4 inhibitor that suppresses autophagy and sensitizes cancer cells to chemotherapy. Theranostics 8(3): 830-845. (IF: 13.3, 7/195(<5%), MEDICINE, RESEARCH & EXPERIMENTAL)

50. PF Liu, Y Wang, RG Ulrich, CW. Simmons, JS. VanderGheynst, RL Gallo, CM Huang^* (2018) Leaf-encapsulated vaccines: agroinfiltration and transient expression of the antigen staphylococcal endotoxin B in radish leaves. Journal of Immunology Research 2018:3710961. (IF: 3.6, 79/183, IMMUNOLOGY)

51. PF Liu^#, HW Chang^#, JS Cheng, HP Lee, CY Yen, WL Tsai, JT Cheng, YJ Li, WC Huang, CH Lee, LP Ger, CW Shu^* (2018) MAPLC3B and SQSTM1 modulated autophagy for tumorigenesis and prognosis in certain subsites of oral squamous cell carcinoma. Journal of Clinical Medicine 7(12):478. (IF: 2.9, 65/332. (<20%), MEDICINE, GENERAL & INTERNAL)

52. YD Tony Tzeng^#, PF Liu^# (co-first author), JY Li, LF Liu, SY Kuo, CW Hsieh, CH Lee, CH Wu, M Hsiao, HT Chang, CW Shu^* (2018) Kinome-wide siRNA screening identifies Src-enhanced resistance of chemotherapeutic drugs in triple-negative breast cancer cells. Frontiers in Pharmacology 2018; 9:1285. (IF: 4.8, 51/352 (<20%), PHARMACOLOGY & PHARMACY)

2017

53. PF Liu^#, CJ Hsu^#, WL Tsai, JS Cheng, JJ Chen, IF Huang, HH Tseng, HW Chang*, CW Shu^* (2017) Ablation of ATG4B suppressed autophagy and activated AMPK for cell cycle arrest in cancer cells.  Cellular Physiology and Biochemistry 44(2):728-740. (IF:2.0, 57/87, PHYSIOLOGY).

54. PF Liu, YC Hu, BH Kang, YK Tseng, PC Wu, CC Liang, YY Hou, TY Fu, HH Liou, IC Hsieh, LP Ger*, CW Shu^*(2017) Expression levels of cleaved Caspase-3 and Caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma. PLoS One 12(7):e0180620. (IF: 2.6, 44/135, MULTIDISCIPLINARY SCIENCES)

55. PF Liu^#, BH Kang^#, YM Wu, JH Sun, LM Yen, TY Fu, YC Lin, HH Liou, YS Lin, HC Sie, IC Hsieh, YK Tseng, CW Shu, YD Hsieh, LP Ger^* (2017) Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial–mesenchymal transition-related proteins. PLoS One 12(6):e0178581 PLoS One 12(7):e0180620. (IF: 2.6, 44/135, MULTIDISCIPLINARY SCIENCES)

56. PF Liu, Y Wang, YT Liu, CM Huang^* (2017) Vaccination with killed but metabolically active E. coli over-expressing hemagglutinin elicits neutralizing antibodies to H1N1 swine origin influenza A virus. Journal of Nature and Science 3(2):e317.

57. Huang JS^#, Yang CM^#, Wang JS, Liou HH, Hsieh IC, Li GC, Huang SJ, Shu CW, Fu TY, Lin YC, Ger LP^*, PF Liu^* (2017) Caspase-3 expression in tumorigenesis and prognosis of buccal mucosa squamous cell carcinoma. Oncotarget 8(48):84237-84247. (2016 IF: 5.168, 44/217, ONCOLOGY)

58. HH Tseng, YK Tseng, JJ You, BH Kang, TH Wang, CM Yang, HC Chen, HH Liou, PF Liu, LP Ger^*, KW Tsai^* (2017) Next-generation sequencing for microRNA Profiling: microRNA-21-3p promotes oral cancer metastasis. Anticancer Research 37(3):1059-1066. (IF: 1.7, 259/326, ONCOLOGY)

2016

59. TY Fu^#, CN Wu^#, HC Sie, JT Cheng, YS Lin, HH Liou, YK Tseng, CW Shu, KW Tsai, LM Yen, HW Tseng, CJ Tseng, LP Ger^*, PF Liu^* (2016) Subsite-specific association of DEAD Box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma. Oncotarget 7(51):85097-85108. (2016 IF: 5.168, 44/217, ONCOLOGY)

60. CW Shu, HT Chang, CS Wu, CH Chen, S Wu, Chang HW, Kuo SY, Fu E, PF Liu^* (co-corresponding author), Hsieh YD^* (2016) RelA-mediated BECN1 expression is required for reactive oxygen species-induced autophagy in oral cancer cells exposed to low-power laser irradiation. PLoS One 11(9):e0160586. (IF: 2.6, 44/135, MULTIDISCIPLINARY SCIENCES)

61. HW Chen, PF Liu, YT Liu, S Kuo, XQ Zhang, RT Schooley, H Rohde, RL Gallo, CM Huang^* (2016) Nasal commensal Staphylococcus Epidermidis counteracts influenza virus. Scientific Reports 6:27870. (IF: 3.9, 25/135(<20%), MULTIDISCIPLINARY SCIENCES)

62. CM Yang, TH Wang, HC Chen, SC Li, MC Lee, HH Liou, PF Liu, YK Tseng, YL Shiue, LP Ger, KW Tsai^* (2016) Aberrant DNA hypermethylation-silenced SOX21-AS1 gene expression and its clinical importance in oral cancer. Clinical Epigenetics 8:129. (IF: 4.4, 34/191 (<20%), GENETICS &HEREDITY)

63. YY Ho, JJ You, CM Yang, HW Pan, HC Chen, JH Lee, YS Lin, HH Liou, PF Liu, LP Ger^*, KW Tsai^*. (2016) Aberrant DNA hypomethylation of miR-196b gene contributes to migration and invasion of oral cancer. Oncology Letters 11(6):4013-4021. (IF: 2.2, 216/326, ONCOLOGY)

2015

64. PF Liu^#, JS Cheng^#, CL Sy^#, WC Huang, HC Yang, RL. Gallo, CM Huang, CW Shu^* (2015) IsaB Inhibits Autophagic flux to promote host transmission of methicillin-resistant Staphylococcus aureus. Journal of Investigative Dermatology 135(11):2714-2722. (IF: 5.7, 7/96 (<10%), DERMATOLOGY).

65. PF Liu, YD Hsieh, YC Lin, A Two, CW Shu^*, CM Huang^* (2015) Propionibacterium acnes in the pathogenesis and immunotherapy of acne vulgaris. Current Drug Metabolism 16(4):245-254. (IF: 1.8, 244/352, PHARMACOLOGY & PHARMACY)

66. WZ Liang^#, PF Liu^# (co-first author), E Fu, HS Chung, CR Jan, CH Wu, CW Shu^*, YD Hsieh^* (2015) Selective cytotoxic effects of low-power laser irradiation on human oral cancer cells. Lasers in Surgery and Medicine 47(9):756-764. (IF: 1.9, 119/312, SURGERY)

67. IF Huang^#, IC Lin^#, PF Liu (co-first author), YC Liu, YD Hsieh, JJ Chen, CL Chen, HW Chang, CW Shu^* (2015) Lactobacillus acidophilus attenuates Salmonella-induced intestinal inflammation via TGF-β signaling. BMC Microbiology 15:203. (IF: 4.2, 46/163, MICROBIOLOGY)

2014

68. PF Liu^#, CM Leung^#, YH Chang, JS Cheng, JJ Chen, CJ Weng, KW Tsai, CJ Hsu, YC Liu, PC Hsu, HW Pan^*, CW Shu^* (2014) ATG4B promotes colorectal cancer growth independent of autophagic flux. Autophagy 10(8):1454-1465. (IF: 14.3, 16/204(<10%), CELL BIOLOGY)

2013

69. PF Liu, IF Huang, CW Shu^*, CM Huang^* (2013) Halitosis vaccines targeting FomA, a biofilm-bridging protein in Fusobacteria nucleatum. Current Molecular Medicine 13(8):1358-1367. (IF: 2.5, 102/195, MEDICINE, RESEARCH & EXPERIMENTAL)

70. WS Chen, TW Chen, TH Yang, LY Hu, HW Pan, CM Leung, SC Li, MR Ho, CW Shu, PF Liu, SY Yu, YT Tu, WC Lin, TT Wu^*, KW Tsai^* (2013) Co-modulated behavior and effects of differentially expressed miRNA in colorectal cancer. BMC Genomics 14 (Suppl 5):S12. (IF: 3.7, 51/191, GENETICS & HEREDITY)

2012

71. CW Shu^*, PF Liu, CM Huang^* (2012) High-throughput screening for drug discovery of autophagy modulators. Combinatorial Chemistry & High Throughput Screening 15(9):721-729. (IF: 1.7, 49/75, CHEMISTRY, APPLIED)

2011

72. PF Liu, T Nakatsuji, W Zhu, RL Gallo, CM Huang^* (2011) Passive immunoprotection targeting a secreted CAMP factor of Propionibacterium acnes as a novel immunotherapeutic for acne vulgaris. Vaccine 29(17):3230-8. (IF: 3.5, 68/195, MEDICINE, RESEARCH & EXPERIMENTAL)

2010

73. PF Liu, WY Shi, WH Zhu, JW Smith, SL Hsieh, RL Gallo, CM Huang^* (2010) Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: implication for treatment of periodontal infection and halitosis. Vaccine 28(19), 3496-3505. (IF: 3.5, 68/195, MEDICINE, RESEARCH & EXPERIMENTAL)

74. CH Chen, XQ Zhang, CW Lo, PF Liu, YT Liu, RL Gallo, MF Hsieh^*, RT Schooley^*, CM Huang^* (2010) The essentiality of alpha-2-macroglobulin in human salivary innate immunity against new H1N1 swine origin influenza a virus. Proteomics 10(12), 2396-2401. (IF: 3.9, 18/86, BIOCHEMICAL RESEARCH METHODS)

75. YK Wang, WC Chang, PF Liu, MK Hsiao, CT Lin, SM Lin, RL Pan^* (2010) Ovate family protein 1 as a plant Ku70 Interacting protein involving in DNA double-strand break repair. Plant Molecular Biology 74(4-5), 453-466. (IF: 3.8, 52/273(<20%), PLANT SCIENCES)

2009

76. PF Liu, WH Zhu, CM Huang^* (2009) Vaccines and photodynamic therapies for oral microbial-related diseases. Current Drug Metabolism 10(1), 90-94. (IF: 1.8, 244/352, PHARMACOLOGY & PHARMACY) 

77. PF Liu, SK Haake, RL. Gallo, CM Huang^* (2009) A novel vaccine targeting Fusobacterium nucleatum against abscesses and halitosis. Vaccine 27(10), 1589-1595. (IF: 3.5, 68/195, MEDICINE, RESEARCH & EXPERIMENTAL)

78. PF Liu, CW Lo, CH Chen, MF Hsien, CM Huang^* (2009) Use of nanoparticles as therapy for methicillin-resistant Staphylococcus aureus infections. Current Drug Metabolism 10 (8), 875-884. (IF: 1.8, 244/352, PHARMACOLOGY & PHARMACY)

79. SH Hsu, YY Hsiao, PF Liu, SM Lin, YY Luo, RL Pan^* (2009) Purification, characterization, and spectral analyses of histidine-tagged vacuolar H+-pyrophosphatase expressed in yeast. Botanical Studies 50, 291-301. (IF: 3.1, 76/273, PLANT SCIENCES)

2008

80. PF Liu, YK Wang, WC Chang, HY Chang, RL Pan^* (2008) Regulation of Arabidopsis thaliana Ku genes at different developmental stages under heat stress. Biochimica et Biophysica Acta- Gene Regulatory Mechanisms 1779 (6-7), 402-407. (IF: 3.1, 23/79, BIOPHYSICS)

81. PF Liu, WC Chang, YK Wang, HY Chang, RL Pan^* (2008) Signaling pathways mediating the suppression of Arabidopsis thaliana Ku gene expression by abscisic acid. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 1779(3), 164-174. (IF: 3.1, 23/79, BIOPHYSICS)

82.  JY Fang, PF Liu, CM Huang^* (2008) Decreasing systemic toxicity via transdermal delivery of anticancer drugs. Current Drug Metabolism 9(7), 592-597. (IF: 1.8, 244/352, PHARMACOLOGY & PHARMACY)

83. CW Shu, FC Sun, JH Cho, CC Lin, PF Liu, PY Chen, MDT Chang, HW Fu, YK Lai^* (2008) GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis. Journal of Cellular Physiology 215(3):627-35. (IF: 4.0, 14/87(<20%), PHYSIOLOGY)  

84. WC Chang^#, YK Wang^#, PF Liu, YF Tsai, LR Kong, CK Lin, CH Yang, RL Pan^* (2008) Regulation of Ku gene promoters in Arabidopsis by hormones and stress. Functional Plant Biology 35(4):265-280. (IF: 2.7, 87/273, PLANT SCIENCE)

2007

85. PF Liu, WC Chang, YK Wang, SB Munisamy, SH Hsu, HY Chang, SH Wu, RL Pan^* (2007) Differential regulation of Ku gene expression in etiolated mung bean hypocotyls by auxins. Biochimica et Biophysica Acta- Gene Regulatory Mechanisms 1769(7-8), 443-454. (IF: 3.1, 23/79, BIOPHYSICS) 

86. YY Hsiao, YJ Pan, SH Hsu, YT Huang, TH Liu, CH Lee, CH Lee, PF Liu, WC Chang, YK Wang, LF Chien, RL Pan^* (2007) Functional roles of arginine residues in mung bean vacuolar H+-pyrophosphatase. Biochimica et Biophysica Acta- Bioenergetics 1767(7):965-73. (IF: 2.7, 34/79, BIOPHYSICS)

2005

87. SY Kuo, LF Chien, RC Van, KH Yan, PF Liu, WC Chang, JK Wang, RL Pan^* (2005) Purification and subunit determination of H+-pyrophosphatase from endoplasmic reticulum-enriched vesicles of mung bean seedlings. Plant Science 169(5), 847-853. (IF: 4.1, 45/273 (<20%), PLANT SCIENCES)

88. SY Kuo, LF Chien, YY Hsiao, RC Van, KH Yan, PF Liu, SJ Mao, RL Pan^* (2005) Proton pumping inorganic pyrophosphatase of endoplasmic reticulum-enriched vesicles from etiolated mung bean seedlings. Journal of Plant Physiology 162(2):129-38. (IF: 4.1, 45/273(<20%), PLANT SCIENCES)

2004

89. KH Yan, PF Liu, HT Tzeng, WC Chang, WG Chou, RL Pan^* (2004) Characterization of DNA end-binding activities in higher plants. Plant Physiology and Biochemistry 42(7-8):617-22. (IF: 5.7, 24/273(<10%), PLANT SCIENCES) 

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