Associate Professor Huang, Bin
植物生理研究室/Laboratory of Plant Physiology
電話:+886-7-312-1101 ext 2704
專長:蛋白質體學、蛋白質轉譯後修飾體學、植物生理學、心血管病理學
學經歷
學歷:
國立台灣大學植物科學研究所博士(2000.09-2006.07)
國立台灣大學植物科學研究所碩士
屏東科技大學農園生產技術系
經歷:
高雄醫學大學 生物醫學暨環境生物學系 主任(2018.08-2024.07)
高雄醫學大學 生物醫學暨環境生物學系 副教授(2015.08-Present)
高雄醫學大學 生物醫學暨環境生物學系 助理教授(2010.08-2015.07)
中央研究院生物醫學研究所心血管疾病組 博士後研究員 (2006.07-2010.07)
銘傳大學生物科技系兼任助理教授(2003.08-2010.07)
專長與研究
專長:
蛋白質體學、蛋白質轉譯後修飾體學、植物生理學、心血管病理學
研究興趣:
蛋白質轉譯後修飾體學 (PTMs)
植物生理學:植物固醇(Phytosterol) 與光型態發生(Photomorphogenesis)
植物基因改造 (GMO):
1.作物抗蟲訊息傳遞之研究
2.生質能源開發
人體醫學:
1. 心血管病理學:
(1) 血液流體力對血管內皮細胞的保護機制
(2) 缺氧/再灌注對內皮細胞的生理機制
(3) 降血脂藥物的多效性(pleitropic effects) 的探討
(4) 高血壓對心肌與內皮細胞的生理研究
(5) 次細胞層次的蛋白質修飾與內皮細胞功能的探討
2. 中草藥開發:植物新藥 (人蔘二元皂苷、冬蟲夏草、植物固醇) 之藥理分子機制
奈米技術:
1. 重大疾病標誌分子(biomarker)之高流量篩選
2. 奈米感測器之開發(nanosensor)
3. 生化光碟片
4. 蛋白質奈米螢光染劑開發
期刊論文
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Bin Huang, Shu Ling Chen and Yih Ming Chen*. Different chilling responses of brassinosteroid-biosynthetic genes in Arabidopsis and mung bean seedlings. Crop, Environment & Bioinformatics. 2006, 3: 123-134.
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Bin Huang, Chien Hua Chu, Shu Ling Chen, Hsueh Fen Juan and Yih Ming Chen*. Proteomics study of mung bean epicotyl regulated by brassinosteroid under chilling condition. Cellular Mol Biol Lett,. 2006, 11: 264-278.
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Bin Huang, Kuo Chin Ni, Shu Ling Chen, Hsueh Fen Juan, Yih Ming Chen*. Elucidating the growth regulation of brassinosteroids in mung bean epicotyls using a proteomics approach. Proteomic Res J, 2008, 1: 1-18.
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Shih Chung Chen#, Bin Huang#, Yu Chi Liu, Kou Gi Shyu, Pen Yuan Lin, Danny Ling Wang*. Acute hypoxia enhances proteins’ S-nitrosylation in endothelial cells. Biochem Biophys Res Commu, 2008, 377: 1274-1278. (Co-first authors)
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Bin Huang, Shih Chung Chen and Danny Ling Wang*. Shear flow increases S-nitrosylation of proteins in endothelial cells. Cardiovasc Res, 2009, 83: 536-546.
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Bin Huang, Chung Ling Liao, Ya Pin Lin, Shih Chung Chen and Danny Ling Wang*. S-nitrosoproteome in endothelial cells revealed by a modified biotin switch approach coupled with western blot-based two-dimensional gel electrophoresis. J Proteome Res, 2009, 8: 4835-4843.
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Chao Ping Wang, Jer Yiing Houng, Hsia Fen Hsu, Han Jung Chen, Bin Huang, Wei Chin Hung, Teng Hung Yu, Cheng An Chiu, Li Fen Lu and Chia Chang Hsu*. Glossogyne Tenuifolia enhances posttranslational S-nitrosylation of proteins in vascular endothelial cells. Taiwania, 2011, 56: 97-104.
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Shih Chung Chen, Yun Lian Lin, Bin Huang, Danny Ling Wang, Jing Jy Cheng*. Salvianolic acid B suppresses IFN-gamma-induced JAK/STAT1 activation in endothelial cells. Thromb Res, 2011, 128: 560-564.
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Bin Huang, Fu An Li, Chien Hsing Wu and Danny Ling Wang*. The role of nitric oxide on rosuvastatin-mediated S-nitrosylation and translational proteomes in human umbilical vein endothelial cells. Proteome Sci, 2012, 10:43.
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Bin Huang, Chien Hsing Wu, Fu An Li, Shih Shin Liang, Ying Hua Shieh, Danny Ling Wang*. Rosuvastatin-regulated post-translational phosphoproteome in human umbilical vein endothelial cells. Kaohsiung J Med Sci, 2013, 29: 347-352.
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Ming Chung Lin, Chung Hsi Hsing, Fu An Li, Chien Hsing Wu, Yaw Syan Fu, Jen Kun Cheng, Bin Huang*. Rosuvastatin modulates the post-translational acetylome in endothelial cells. Acta Cardiol Sin, 2014, 30: 67-73.
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Hsyue-Jen Hsieh, Ching-Ann Liu, Bin Huang, Anne H.H. Tseng and Danny Ling Wang*. Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications. J Biomed Sci. 2014, 21:3.
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Ying Hua Shieh, Chien Chuan Chen, Fu An Li, Jen Kun Cheng, Ming Chung Lin, Bin Huang*. The translational proteome modulated by 20(S)-protopanaxadiol in endothelial cells. Acta Cardiol Sin, 2014, 30(5):466-473.
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Ping Ho Chen, Yaw Syan Fu, Yun-Ming Wang, Kun-Han Yang, Danny Ling Wang, Bin Huang*. Hydrogen sulfide increases nitric oxide production and subsequent S-nitrosylation in endothelial cells. Sci World J, v.2014. Article ID 480387.
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Ping Ho Chen, Ka Wo Lee, Cheng Chieh Hsue, Jeff Yi Fu Chenf, Yan Hsiung, Wang, Ker Kong Chen, Hurng Wern Huang*, Bin Huang*. Expression of a splice variant of CYP26B1 in betel quid-related oral cancer*. Sci World J, 2014, v.2014, Article ID 810561.
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Bin Huang, Kuo Hao Chiang, Hsin Su Yu, Ying Lun Chen, Huey Ling You, Wei Ting Liao*. Arsenic modulates translational proteome and protein S-nitrosylation in keratinocytes. Sci World J, 2014, 2014: 360153.
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Yung Chieh Tsai, Yen Ni Teng, Jui Hsiang Hung, Chien Hsing Wu, Yu Ting Kuo, Pao Lin Kuo, Chien Chih Chiu, Bin Huang*. Leucine rich domain associates the stability of LRWD1 protein in spermatogenic cells. Adv Med Sci 2014, 59: 266-272..
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Ping Ho Chen, Bin Huang, T. Y. Shieh, Yan Hsiung Wang, Yuk Kwan Chen, Ju Hui Wu, Jhen Hao Huang, Chun Chia Chen, Ka Wo Lee*. The influence of monoamine oxidase variants on the risk of betel quid-associated oral and pharyngeal cancer. Sci World J 2014, 2014: 183548.
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Bin Huang, Chang-Ting Chen, Chi-Shia Chen, Yun-Ming Wang, Hsyue-Jen Hsieh*, Danny Ling Wang*. Laminar shear flow increases hydrogen sulfide and activates a nitric oxide producing signaling cascade in endothelial cells. Biochem Biophys Res Commu, 2015, 464(4): 1254-1259.
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Tsan-Wan Chiu, Ying-Lun Chen, Chien-Yi Wu, Pei-Ling Yu, Ying-Hua Shieh, Bin Huang*. Hydrogen sulfide modulates the S-nitrosoproteome and the mitochondrial morphology in endothelial cells. Acta Cardiol Sin, 2016, 32(5): 604-611.
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Ching Jung Hsieh*, Bin Huang. Rosuvastatin decreases testosterone levels but not sexual function in men with type 2 diabetes. Diabetes Res Clin Pract, 2016, 120: 81-8.
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Bin Huang*, Jen-Kun Cheng, Chien-Yi Wu, Ping-Ho Chen, Po-Shu Tu, Yaw-Syan Fu, Chien-Hsing Wu. Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells. Vascul Pharmacol, 2017, 90: 27-35.
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Hsiao-Hang Chung, Shu-Kai Shi, Bin Huang, Jen-Tsung Chen*. Enhanced Agronomic Traits and Medicinal Constituents of Autotetraploids in Anoectochilus formosanus Hayata, a Top-Grade Medicinal Orchid. Molecules, 2017, 22(11): 1907.
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Yi-Chieh Wang, Meng-Ze Lin, Bin Huang, Hsiao-Hang Chung, Jen-Tsung Chen*. Thidiazuron enhanced somatic embryogenesis from callus lines of Arabica coffee and subsequent plant regeneration. Acta biol Cracoviensia, Series botanica, 2018, 60(2): 35-44.
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Wan-Jung Chuang, Manmath Narwane, Hsing-Yin Chen, Chai-Lin Kao, Bin Huang, Kuang-Mei Hsu, Yun-Ming Wang, Sodio C. N. Hsu*. Nitric oxide-release study of a bio-inspired copper(I)-nitrito complex under chemical and biological conditions. Dalton Trans, 2018, 47: 13151.
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Ming-Hui Yang, Wan-Jou Chen, Yaw-Syan Fu, Bin Huang, Wan-Chi Tsai, Yi-Ming Arthur Chen, Po-Chiao Lin, Cheng-Hui Yuan, Yu-Chang Tyan*. Utilizing glycine N-methyltransferasegene knockout mice as a model for identification of missing proteins in hepatocellular carcinoma. Oncotarget, 2018, 9(1):442-452.
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Chien-Hsing Wu, Chih-Chao Yang, Hsueh-Wen Chang, Bin Huang, Chung-Jen Chen, Eton I-Cheng Lin, Chien-Yi Wu, Yueh-Hua Chung, Yu-Han Hsu, Chien-Te Lee, Feng-Rong Chuang*. Urinary uromodulin/creatinine ratio as a potential clinical biomarker for chronic kidney disease patients with gout: a pilot study. Med Princ Pract, 2019, 28(3): 273-279.
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Ping-Ho Chen, Chia-Min Chung, Yen-Yun Wang, Hurng-Wern Huang, Bin Huang, Ka-Wo Lee, Shyng-Shiou Yuan, Che-Wei Wu, Lee-Shuan Lin, Leong-Perng Chan*. CYP26A1 Is a Novel Biomarker for Betel Quid-Related Oral and Pharyngeal Cancers. Diagnostics (Basel), 2020, 10(11):982.
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Wun-Rong Lin, Chung-Jung Liu, Yaw-Syan Fu, Fu-An Li, Bin Huang*. Comparison of the protein acetylome of endothelial cells upon shear flow and resveratrol treatment. Cardiol J, 2020, doi: 10.5603/CJ.a2020.0029.
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Chien-Yi Wu, Wun-Rong Lin, Cherng-Jye Jeng, Chien-Hsing Wu, Bin Huang*. Arecoline increases the production of nitric oxide and post-translational S-nitrosoproteome in endothelial cells. Curr Proteomics, 2020, 17. 10.2174/1570164617666191003112053
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Revathi Gurunathan, Bin Huang, Vinoth Kumar Ponnusamy, Jiang-Shiou Hwang, Hans-Uwe Dahms*. Novel recombinant keratin degrading subtilisin like serine alkaline protease from Bacillus cereus isolated from marine hydrothermal vent crabs. Sci Rep, 2021, 11(1): 12007.
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Hao-Yu Liu, Chi-Fen Chang, Cheng-Chang Lu, Shun-Cheng Wu, Bin Huang, Tsung-Lin Cheng, Sung-Yen Lin, Cheng-Jung Ho, Mon-Juan Lee, Chung-Da Yang, Ying-Chun Wang, Jhong-You Li, Ping-Cheng Liu, Chun-Wang Wei, Lin Kang, Chung-Hwan Chen*. The role of mitochondrial metabolism, AMPK-SIRT mediated pathway, lncRNA and microRNA in osteoarthritis. Biomedicines, 2022, 10(7): 1477.
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Fu-Chen Kuo, Hsin-Yi Tsai, Bi-Ling Cheng, Kuen-Jang Tsai, Ping-Chen Chen, Yaw-Bin Huang, Chung-Jung Liu, Deng-Chyang Wu, Meng-Chieh Wu, Bin Huang*, Ming-Wei Lin*. Endothelial mitochondria transfer to melanoma induces M2-type macrophage polarization and promotes tumor growth by the Nrf2/HO-1-mediated pathway. Int J Mol Sci, 2024, 25(3): 1857.
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Yung-Shun Su, Ming-Jen Cheng, Aij-Lie Kwan, Shu-Ping Huang, Yu-Chang Tyan, Chee-Yin Chai*, Bin Huang*. The crude extract obtained from Cinnamomum macrostemon Hayata regulates oxidative stress and mitophagy in keratinocytes. Biosci Biotech Biochem, 2024, (Accept)
20240315update