Associate Professor Chang, Yung-Fu
電話:+886-7-3121101 ext 2701
專長:生物化學、分子生物學
專長與研究
專長:
生物化學、分子生物學
研究領域:
生物化學
分子生物學
細胞凋亡之調控
神經及肌肉細胞之生長與分化
基因建構及基因的過度表現
Gene knockdown cell model (基因減弱細胞模式)
Transgenic and knockout mouse animal molde (基因轉殖及基因剔除老鼠動物模式)
期刊論文
- Chang, Y.-F., Tong, W.-H., and Yuo, C.-Y., 1995. Expression of a Drosophila cell death protein in E.coli and mammalian cells. The 10th Joint Ann. Conf.Biomed. Sci., Taipei, Taiwan.
- Chang, Y.-F., Tseng, C.-S., and Yuo, C.-Y., 1996. Expression and functional studies of Drosophila cell death protein, Reaper. Fourth Symposium on Recent Advance in Cellular and Molecular Biology, Kenting, Taiwan.
- Chang, Y.-F., Tseng, C.-S., and Yuo, C.-Y., 1996. Drosophila cell death protein, Reaper, is expressed in embryos as a doublet. The 11th Joint Ann. Conf.Biomed. Sci., Taipei, Taiwan.
- Cheng CM, Chang YF, Yuo CY*. Sequence of a human E2F-4 pseudogene with shortened AGC trinucleotide repeats. 1997, Kaohsiung J Med Sci. 13(7):448-52.
- Cheng CM, Huang SP, Chang YF, Chung WY, Yuo CY*. The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1. 2003, Biochem. Biophys. Res. Commun. 30;305(2):359-64. (SCI, IF 2.935, BIOPHYSICS 18/63, BIOCHEMISTRY & MOLECULAR BIOLOGY 103/260)
- Chang YF, Wei J, Liu X, Chen YH, Layne MD, Yet SF*. Identification of a CArG-independent region of the cysteine-rich protein 2 promoter that directs expression in the developing vasculature. 2003,Am J Physiol Heart Circ Physiol.285(4):H1675-83.(SCI, IF 3.369, CARDIAC & CARDIOVASCULAR SYSTEMS 8/66, PHYSIOLOGY 14/73, PERIPHERAL VASCULAR DISEASE 11/52 )
- Lee, Y.-H., Cheng, C.-M., Chang, Y.-F., Wang, T.-Y., and Yuo, C.-Y.*. Apoptin T108 phosphorylation is not required for its tumor-specific nuclear localization but partially affects its apoptotic activity. 2007. Biochem. Biophys. Res. Commun. 354(2):391-5. (SCI, IF 3.000, BIOPHYSICS 21/65, BIOCHEMISTRY & MOLECULAR BIOLOGY 97/261)
- Liang WC, Yuo CY, Chang JG, Chen YC, Chang YF, Wang HY, Ju YH, Chiou SS, Jong YJ*. The effect of hydroxyurea in spinal muscular atrophy cells and patients. 2008. J Neurol Sci.268(1-2):87-94. (SCI, IF 2.412, CLINICAL NEUROLOGY 50/146)
- Wang CC, Chang JG, Ferrance J, Chen HY, You CY, Chang YF, Jong YJ, Wu SM*, Yeh CH. Quantification of SMN1 and SMN2 genes by capillary electrophoresis for diagnosis of spinal muscular atrophy. 2008. Electrophoresis. 29(13):2904-11. (SCI, IF 3.609, CHEMISTRY, ANALYTICAL, 6/70, BIOCHEMICAL RESEARCH METHODS 16/60 )
- Ting-Yuan Liu, Chung-Yee Yuo, Cheng-Hsing Kao, Chao-Neng Tseng, Yuh-Jyh Jong, Jan-Gowth Chang , Shou-Mei Wu, Yung-Fu Chang*. Hydrogen peroxide decreases the survival rate of HeLa cells with stable knockdown of SMN protein. 2011. Kaohsiung J Med Sci. 27(3):102-7. (SCI, IF 0.607, MEDICINE, RESEARCH & EXPERIMENTAL 84/93)
- Fang-Rong Chang, Yi-Chung Hsieh, Yung-Fu Chang, Kuo-Hsiung Lee, Yang-Chang Wu, Li-Kwan Chang*. Inhibition of the Epstein-Barr virus lytic cycle by moronic acid. 2010. Antiviral Res. 85(3):490-5. (JCR 2009: SCI, IF 3.612, PHARMACOLOGY & PHARMACY 50/237 =21.09%, VIROLOGY 8/30) 2010/03
- Shao-Tung Liu, Gau-Chyi Young, Yi-Chen Lee, Yung-Fu Chang*. A preliminary report on the toxicity of arecoline on early pregnancy in mice. 2011. Food Chem. Toxicol. 49(1):144-148. (JCR 2010: SCI, IF 2.602, FOOD SCIENCE & TECHNOLOGY 16/128 =12.5%, TOXICOLOGY 32/83) 2011/01
- Ting-Yuan Liu, Chung-Yee Yuo, Cheng-Hsing Kao, Chao-Neng Tseng, Yuh-Jyh Jong, Jan-Gowth Chang , Shou-Mei Wu, Yung-Fu Chang*. Hydrogen peroxide decreases the survival rate of HeLa cells with stable knockdown of SMN protein. 2011. Kaohsiung J Med Sci. 27(3):102-7. (JCR 2010: SCI, IF 0.474, MEDICINE, RESEARCH & EXPERIMENTAL 92/106 =86.79%) 2011/03
- Yung-Fu Chang, Hui-Ju Chou, Ying-Cheng Yen, Chiu-Chin Lu, Hurng-Wern Huang, Chung-Lung Cho, Hsueh-Wei Chang, Chao-Neng Tseng*. Agrin induces Association of Chrna1 mRNA and Nicotinic Acetylcholine Receptor in C2C12 Myotubes. 2012. FEBS lett. 21;586(19):3111-6. (JCR 2011: SCI, IF 3.538, BIOPHYSICS 21/74 =28.38%, BIOCHEMISTRY & MOLECULAR BIOLOGY 102/290, CELL BIOLOGY 82/181) 2012/09
- Yung-Fu Chang, Ting-Yuan Liu, Shao-Tung Liu, Chao-Neng Tseng *. Arecoline inhibits myogenic differentiation of C2C12 myoblasts by reducing STAT3 phosphorylation. 2012. Food Chem. Toxicol. 50(10):3433-3439. (JCR 2011: SCI, IF 2.999, FOOD SCIENCE & TECHNOLOGY 13/128 =10.16%, TOXICOLOGY 25/83) 2012/10
- Chao-Neng Tseng, Chien-Fu Huang, Chung-Lung Cho, Hsueh-Wei Chang, Chao-Wei Huang, Chien-Chih Chiu*, and Yung-Fu Chang*. Brefeldin A Effectively Inhibits Cancer Stem Cell Properties and MMP-9 Activity in Human Colorectal Cancer Colo 205 cells. 2013. Molecules. 18(9), 10242-10253. (JCR 2012: SCI, IF 2.428, CHEMISTRY, ORGANIC 24/57 =42.11%). 2013/08
- Chao-Neng Tseng, Chung-Lung Cho, Tzan-Wen Chen, Chien-Chih Chiu, Hsueh-Wei Chang, Fang-Rong Chang*, Yung-Fu Chang*. Brefeldin A inhibits Cancer Stem Cell Properties in Human Lung Cancer Cells. 2013. Curr. Signal Transduct. Ther. 8(2):113-118. (JCR 2012: SCI, IF 0.446, PHARMACOLOGY & PHARMACY 236/260 =90.77%). 2013/08
- Yung-Fu Chang*, Ting-Yuan Liu, Shao-Tung Liu. Arecoline inhibits and destabilizes agrin-induced acetylcholine receptor cluster formation in C2C12 myotubes. 2013. Food Chem. Toxicol. 60: 391-6. (JCR 2012: SCI, IF 3.010, FOOD SCIENCE & TECHNOLOGY 12/124=9.68%, TOXICOLOGY 27/85=31.76%). 2013/10
-
Ting-Yuan Liu, Yu-Chia Chen, Yuh-Jyh Jong, Huai-Jen Tsai, Chien-Chin Lee, Ya-Sian Chang, Jan-Gowth Chang*,Yung-Fu Chang*. Muscle Developmental Defects in Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNP A1) Knockout Mice. Open Biology. 2017 ;7(1). pii: 160303.
-
Amirhossein Hakamivala, YiHui Huang, Yung-Fu Chang, Zui Pan, Ashwin Nair, Jer-Tsong Hsieh, and Liping Tang*. Development of 3D Lymph Node Mimetic for Studying Prostate Cancer Metastasis. Advanced Biosystems. 2019, 3(9):1900019.
-
Yi-Xuan Li, Chun-Hung Hsiao, Yung-Fu Chang*. N-acetyl cysteine prevents arecoline-inhibited C2C12 myoblast differentiation through ERK1/2 phosphorylation. PLoS One. 2022 Jul 28;17(7):e0272231.
-
Pei-Feng Liu, Yung-Fu Chang*. The Controversial Roles of Areca Nut: Medicine or Toxin?. Int. J. Mol. Sci. 2023, 24(10), 8996.
-
Yung-Fu Chang, Hsing-Hsang Wang, Chih-Wen Shu, Wei-Lun Tsai, Cheng-Hsin Lee, Chun-Lin Chen, Pei-Feng Liu*. TMEM211 Promotes Tumor Progression and Metastasis in Colon Cancer. Curr. Issues Mol. Biol. 2023, 45(6), 4529-4543.