教學

目前開授：
　　開授：(大學部) 植物組織培養及基因工程、植物生理學、基因體學
　　分授：(大學部) 普通生物學、普通生物學實驗

專長與研究

專長：

　　蛋白質體學、蛋白質轉譯後修飾體學、植物生理學、心血管病理學

研究興趣：

　　蛋白質轉譯後修飾體學 (PTMs)

　　植物生理學：植物固醇(Phytosterol) 與光型態發生(Photomorphogenesis)

　　植物基因改造 (GMO)：

　　　1.作物抗蟲訊息傳遞之研究

　　　2.生質能源開發

　　人體醫學：

　　　1. 心血管病理學：

　　　　(1) 血液流體力對血管內皮細胞的保護機制

　　　　(2) 缺氧/再灌注對內皮細胞的生理機制

　　　　(3) 降血脂藥物的多效性(pleitropic effects) 的探討

　　　　(4) 高血壓對心肌與內皮細胞的生理研究

　　　　(5) 次細胞層次的蛋白質修飾與內皮細胞功能的探討

　　　2. 中草藥開發：植物新藥 (人蔘二元皂苷、冬蟲夏草、植物固醇) 之藥理分子機制

　　奈米技術：

　　　1. 重大疾病標誌分子(biomarker)之高流量篩選

　　　2. 奈米感測器之開發(nanosensor)

　　　3. 生化光碟片

　　　4. 蛋白質奈米螢光染劑開發

期刊論文

1. Bin Huang, Shu Ling Chen and Yih Ming Chen*. Different chilling responses of brassinosteroid-biosynthetic genes in Arabidopsis and mung bean seedlings. Crop, Environment & Bioinformatics. 2006, 3: 123-134.

2. Bin Huang, Chien Hua Chu, Shu Ling Chen, Hsueh Fen Juan and Yih Ming Chen*. Proteomics study of mung bean epicotyl regulated by brassinosteroid under chilling condition. Cellular Mol Biol Lett,. 2006, 11: 264-278. 

3. Bin Huang, Kuo Chin Ni, Shu Ling Chen, Hsueh Fen Juan, Yih Ming Chen*. Elucidating the growth regulation of brassinosteroids in mung bean epicotyls using a proteomics approach. Proteomic Res J, 2008, 1: 1-18.

4. Shih Chung Chen#, Bin Huang#, Yu Chi Liu, Kou Gi Shyu, Pen Yuan Lin, Danny Ling Wang*. Acute hypoxia enhances proteins’ S-nitrosylation in endothelial cells. Biochem Biophys Res Commu, 2008, 377: 1274-1278. (Co-first authors)

5. Bin Huang, Shih Chung Chen and Danny Ling Wang*. Shear flow increases S-nitrosylation of proteins in endothelial cells. Cardiovasc Res, 2009, 83: 536-546.

6. Bin Huang, Chung Ling Liao, Ya Pin Lin, Shih Chung Chen and Danny Ling Wang*. S-nitrosoproteome in endothelial cells revealed by a modified biotin switch approach coupled with western blot-based two-dimensional gel electrophoresis. J Proteome Res, 2009, 8: 4835-4843.

7. Chao Ping Wang, Jer Yiing Houng, Hsia Fen Hsu, Han Jung Chen, Bin Huang, Wei Chin Hung, Teng Hung Yu, Cheng An Chiu, Li Fen Lu and Chia Chang Hsu*. Glossogyne Tenuifolia enhances posttranslational S-nitrosylation of proteins in vascular endothelial cells. Taiwania, 2011, 56: 97-104.

8. Shih Chung Chen, Yun Lian Lin, Bin Huang, Danny Ling Wang, Jing Jy Cheng*. Salvianolic acid B suppresses IFN-gamma-induced JAK/STAT1 activation in endothelial cells. Thromb Res, 2011, 128: 560-564.

9. Bin Huang, Fu An Li, Chien Hsing Wu and Danny Ling Wang*. The role of nitric oxide on rosuvastatin-mediated S-nitrosylation and translational proteomes in human umbilical vein endothelial cells. Proteome Sci, 2012, 10:43.

10. Bin Huang, Chien Hsing Wu, Fu An Li, Shih Shin Liang, Ying Hua Shieh, Danny Ling Wang*. Rosuvastatin-regulated post-translational phosphoproteome in human umbilical vein endothelial cells. Kaohsiung J Med Sci, 2013, 29: 347-352.

11. Ming Chung Lin, Chung Hsi Hsing, Fu An Li, Chien Hsing Wu, Yaw Syan Fu, Jen Kun Cheng, Bin Huang*. Rosuvastatin modulates the post-translational acetylome in endothelial cells. Acta Cardiol Sin, 2014, 30: 67-73.

12. Hsyue-Jen Hsieh, Ching-Ann Liu, Bin Huang, Anne H.H. Tseng and Danny Ling Wang*. Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications. J  Biomed Sci. 2014, 21:3.

13. Ying Hua Shieh, Chien Chuan Chen, Fu An Li, Jen Kun Cheng, Ming Chung Lin, Bin Huang*. The translational proteome modulated by 20(S)-protopanaxadiol in endothelial cells. Acta Cardiol Sin, 2014, 30(5):466-473.

14. Ping Ho Chen, Yaw Syan Fu, Yun-Ming Wang, Kun-Han Yang, Danny Ling Wang, Bin Huang*. Hydrogen sulfide increases nitric oxide production and subsequent S-nitrosylation in endothelial cells. Sci World J, v.2014. Article ID 480387.

15. Ping Ho Chen, Ka Wo Lee, Cheng Chieh Hsue, Jeff Yi Fu Chenf, Yan Hsiung, Wang, Ker Kong Chen, Hurng Wern Huang^*, Bin Huang*. Expression of a splice variant of CYP26B1 in betel quid-related oral cancer*. Sci World J, 2014, v.2014, Article ID 810561.

16. Bin Huang, Kuo Hao Chiang, Hsin Su Yu, Ying Lun Chen, Huey Ling You, Wei Ting Liao*. Arsenic modulates translational proteome and protein S-nitrosylation in keratinocytes. Sci World J, 2014, 2014: 360153.

17. Yung Chieh Tsai, Yen Ni Teng, Jui Hsiang Hung, Chien Hsing Wu, Yu Ting Kuo, Pao Lin Kuo, Chien Chih Chiu, Bin Huang*. Leucine rich domain associates the stability of LRWD1 protein in spermatogenic cells. Adv Med Sci 2014, 59: 266-272..

18. Ping Ho Chen, Bin Huang, T. Y. Shieh, Yan Hsiung Wang, Yuk Kwan Chen, Ju Hui Wu, Jhen Hao Huang, Chun Chia Chen, Ka Wo Lee*. The influence of monoamine oxidase variants on the risk of betel quid-associated oral and pharyngeal cancer. Sci World J 2014, 2014: 183548.

19. Bin Huang, Chang-Ting Chen, Chi-Shia Chen, Yun-Ming Wang, Hsyue-Jen Hsieh*, Danny Ling Wang^*. Laminar shear flow increases hydrogen sulfide and activates a nitric oxide producing signaling cascade in endothelial cells. Biochem Biophys Res Commu, 2015, 464(4): 1254-1259.

20. Tsan-Wan Chiu, Ying-Lun Chen, Chien-Yi Wu, Pei-Ling Yu, Ying-Hua Shieh, Bin Huang*. Hydrogen sulfide modulates the S-nitrosoproteome and the mitochondrial morphology in endothelial cells. Acta Cardiol Sin, 2016, 32(5): 604-611.

21. Ching Jung Hsieh*, Bin Huang. Rosuvastatin decreases testosterone levels but not sexual function in men with type 2 diabetes. Diabetes Res Clin Pract, 2016, 120: 81-8.

22. Bin Huang*, Jen-Kun Cheng, Chien-Yi Wu, Ping-Ho Chen, Po-Shu Tu, Yaw-Syan Fu, Chien-Hsing Wu. Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells. Vascul Pharmacol, 2017, 90: 27-35.

23. Hsiao-Hang Chung, Shu-Kai Shi, Bin Huang, Jen-Tsung Chen*. Enhanced Agronomic Traits and Medicinal Constituents of Autotetraploids in Anoectochilus formosanus Hayata, a Top-Grade Medicinal Orchid. Molecules, 2017, 22(11): 1907.

24. Yi-Chieh Wang, Meng-Ze Lin, Bin Huang, Hsiao-Hang Chung, Jen-Tsung Chen*. Thidiazuron enhanced somatic embryogenesis from callus lines of Arabica coffee and subsequent plant regeneration. Acta biol Cracoviensia, Series botanica, 2018, 60(2): 35-44.

25. Wan-Jung Chuang, Manmath Narwane, Hsing-Yin Chen, Chai-Lin Kao, Bin Huang, Kuang-Mei Hsu, Yun-Ming Wang, Sodio C. N. Hsu*. Nitric oxide-release study of a bio-inspired copper(I)-nitrito complex under chemical and biological conditions. Dalton Trans, 2018, 47: 13151.

26. Ming-Hui Yang, Wan-Jou Chen, Yaw-Syan Fu, Bin Huang, Wan-Chi Tsai, Yi-Ming Arthur Chen, Po-Chiao Lin, Cheng-Hui Yuan, Yu-Chang Tyan*. Utilizing glycine N-methyltransferasegene knockout mice as a model for identification of missing proteins in hepatocellular carcinoma. Oncotarget, 2018, 9(1):442-452.

27. Chien-Hsing Wu, Chih-Chao Yang, Hsueh-Wen Chang, Bin Huang, Chung-Jen Chen, Eton I-Cheng Lin, Chien-Yi Wu, Yueh-Hua Chung, Yu-Han Hsu, Chien-Te Lee, Feng-Rong Chuang*. Urinary uromodulin/creatinine ratio as a potential clinical biomarker for chronic kidney disease patients with gout: a pilot study. Med Princ Pract, 2019, 28(3): 273-279.

28. Ping-Ho Chen, Chia-Min Chung, Yen-Yun Wang, Hurng-Wern Huang, Bin Huang, Ka-Wo Lee, Shyng-Shiou Yuan, Che-Wei Wu, Lee-Shuan Lin, Leong-Perng Chan*. CYP26A1 Is a Novel Biomarker for Betel Quid-Related Oral and Pharyngeal Cancers. Diagnostics (Basel), 2020, 10(11):982.

29. Wun-Rong Lin, Chung-Jung Liu, Yaw-Syan Fu, Fu-An Li, Bin Huang*. Comparison of the protein acetylome of endothelial cells upon shear flow and resveratrol treatment. Cardiol J, 2020, doi: 10.5603/CJ.a2020.0029.

30. Chien-Yi Wu, Wun-Rong Lin, Cherng-Jye Jeng, Chien-Hsing Wu, Bin Huang*. Arecoline increases the production of nitric oxide and post-translational S-nitrosoproteome in endothelial cells. Curr Proteomics, 2020, 17. 10.2174/1570164617666191003112053

31. Revathi Gurunathan, Bin Huang, Vinoth Kumar Ponnusamy, Jiang-Shiou Hwang, Hans-Uwe Dahms*. Novel recombinant keratin degrading subtilisin like serine alkaline protease from Bacillus cereus isolated from marine hydrothermal vent crabs. Sci Rep, 2021, 11(1): 12007.

32. Hao-Yu Liu, Chi-Fen Chang, Cheng-Chang Lu, Shun-Cheng Wu, Bin Huang, Tsung-Lin Cheng, Sung-Yen Lin, Cheng-Jung Ho, Mon-Juan Lee, Chung-Da Yang, Ying-Chun Wang, Jhong-You Li, Ping-Cheng Liu, Chun-Wang Wei, Lin Kang, Chung-Hwan Chen*. The role of mitochondrial metabolism, AMPK-SIRT mediated pathway, lncRNA and microRNA in osteoarthritis. Biomedicines, 2022, 10(7): 1477.

33. Fu-Chen Kuo, Hsin-Yi Tsai, Bi-Ling Cheng, Kuen-Jang Tsai, Ping-Chen Chen, Yaw-Bin Huang, Chung-Jung Liu, Deng-Chyang Wu, Meng-Chieh Wu, Bin Huang*, Ming-Wei Lin*. Endothelial mitochondria transfer to melanoma induces M2-type macrophage polarization and promotes tumor growth by the Nrf2/HO-1-mediated pathway. Int J Mol Sci, 2024, 25(3): 1857.

34. Yung-Shun Su, Ming-Jen Cheng, Aij-Lie Kwan, Shu-Ping Huang, Yu-Chang Tyan, Chee-Yin Chai*, Bin Huang*. The crude extract obtained from Cinnamomum macrostemon Hayata regulates oxidative stress and mitophagy in keratinocytes. Biosci  Biotech Biochem, 2024, (Accept)

20240315update