Associate Professor Yuo, Chung-Yee
專長：細胞分子生物學、分子遺傳學、生物技術
學經歷
最高學歷：
美國耶魯大學分子生物學博士
經歷：
高雄醫學大學生物醫學暨環境生物學系副教授 (1992 至今)
高雄醫學大學附設醫院臨床醫學研究部分子生物研究室主任 (2006-2007)
高雄醫學大學生物學系副教授兼系主任 (2000-2003)
中央研究院生物醫學研究所博士後研究 (1989-1992)
專長與研究
專長：
細胞分子生物學, 分子遺傳學, 生物技術
研究領域：
脊髓肌肉萎縮症之分子致病機制及藥物篩選
探討Nmi調控的基因及其在癌細胞轉移中的角色
先天性神經肌肉疾病之分子遺傳分析
雞貧血病毒蛋白Apoptin誘發細胞凋亡之分子機制
期刊論文
1. Liang, W.-C., Tian, X., Yuo, C.-Y., Chen, W.-Z., Kan, T.-M., Su, Y.-N., Nishino, I., Wong, L.-C., and Jong, Y.-J. (2017) Comprehensive target capture/next-generation sequencing as a second-tier diagnostic approach for congenital muscular dystrophy in Taiwan. PLoS One. 12(2):e0170517.
2. Chen, Y.-C., Chang, J.-G., Liu, T.-Y., Jong, Y.-J., Cheng, W.-L., and Yuo, C.-Y.* (2017) Securinine enhances SMN2 exon 7 inclusion in spinal muscular atrophy cells. Biomed. Pharmacother. 88:708-714.
3. Chang, Y.-C., Chiu, C.-C., Yuo, C.-Y., Chan, W.-L., Chang, Y.-S., Chang, W.-H., Wu, S.-M., Chou, H.-L., Liu, T.-C., Lu, C.-Y., Yang, W.-K., and Chang, J.-G. (2016) An XIST-related small RNA regulates KRAS G-quadruplex formation beyond X-inactivation. Oncotarget. 7(52):86713-86729.
4. Chen, Y.-C., Chang, J.-G., Jong, Y.-J., Liu, T.-Y., and Yuo, C.-Y.* (2015) High expression level of Tra2-β1 is responsible for increased SMN2 exon 7 inclusion in the testis of SMA mice. PLoS One. 10(3):e0120721.
5. Chan, W.-L., Yuo, C.-Y., Yang, W.-K., Hung, S.-Y., Chang, Y.-S., Chiu, C.-C., Yeh, K.-T., Huang, H.-D., and Chang, J.-G. (2013) Transcribed pseudogene ψPPM1K generates endogenous siRNA to suppress oncogenic cell growth in hepatocellular carcinoma. Nucleic Acids Res. 41(6):3734-47.
6. Liu, T.-Y., Yuo, C.-Y., Kao, C.-H., Tseng, C.-N., Jong, Y.-J., Chang, J.-G., Wu, S.-M., and Chang, Y.-F. (2011) Hydrogen peroxide decreases the survival rate of HeLa cells with stable knockdown of survival motor neuron protein. Kaohsiung J. Med. Sci. 27, 102-107.
7. Chen, Y.-C., Yuo, C.-Y., Yang, W.-K., Jong, Y.-J., Lin, H.-H., Chang, Y.-S., and Chang, J.-G. (2008) Extracellular pH change modulates the exon 7 splicing in SMN2 mRNA. Mol. Cell. Neurosci. 39(2):268-72.
8. Liang, W.-C.#, Yuo, C.-Y.#, Chang, J.-G., Chen, Y.-C., Wang, H.-Y., Ju, Y.-H., Chiou, S.-S., and Jong, Y.-J. (2008) The effect of hydroxyurea in spinal muscular atrophy cells and patients. J. Neurol. Sci. 268, 87-94. (#equal contribution)
9. Yuo, C.-Y., Lin, H.-H., Chang, Y.-S., Yang, W.-K., and Chang, J.-G. (2008) 5-(N-ethyl-N-isopropyl)-amiloride enhances SMN2 exon 7 inclusion and protein expression in spinal muscular atrophy cells. Ann. Neurol. 63, 26-34.
10. Lee, Y.-H., Cheng, C.-M., Chang, Y.-F., Wang, T.-Y., and Yuo, C.-Y.* (2007) Apoptin T108 phosphorylation is not required for its tumor-specific nuclear localization but partially affects its apoptotic activity. Biochem. Biophys. Res. Commun. 354, 391-395.
