Teaching

Courses Offered：
　　Molecular Biology, Cell Biology, General Biology (Including Laboratory), Molecular Biotechnology

Specialty & Research Interests

Specialty：

　　Cancer Biology, Bacterial infection, Biomarker screening, Clinical data analysis, Immunohistochemistry, Target therapy and vaccine development

Research Interests：

　　Screening of biomarkers for cancers and bacterial infections for: (1) exploring their molecular mechanisms; (2) application in diagnosis/prognosis, targeted therapy, and vaccine development.

Publications

 Publications：(*: corresponding author)

1.   HC Chen, YK Tseng, CW Shu, TJ Weng, HH Liou, LM Yen, IC Hsieh, CC Wang, PC Wu, YL Shiue, TY Fu, KW Tsai, LP Ger, PF Liu*(2019) “Differential Clinical Significance of COL5A1 and COL5A2 in Tongue Squamous Cell Carcinoma” Journal of Oral Pathology & Medicine 48(6):468-476. (IF:2.030, 28/90, DENTISTRY,ORAL,SURGERY &MEDICINE)

2.   BH Kang, CW Shu, JK Chao, CH Lee, TY Fu, HH Liou, LP Ger, PF Liu* (2019) “HSPD1 Repressed E-cadherin Expression to Promote Cell Invasion and Migration for Poor Prognosis in Oral Squamous Cell Carcinoma” Scientific Reports 9:8932. (IF: 4.011, 15/69, MULTIDISCIPLINARY SCIENCES)

3.   JS Cheng^#, WL Tsai^#, PF Liu^#(co-first author), YG Goan, CW Lin, HH Tseng, CH Lee, CW Shu* (2019) “The MAP3K7-mTOR Axis Promotes the Proliferation and Malignancy of Hepatocellular Carcinoma Cells” Frontiers in Oncology 9:474. (IF: 4.134, 70/229, ONCOLOGY)

4.  HW Chang^#, PF Liu^#(co-first author), WL Tsai, WH Hu, YC Hu, HC Yang, WY Lin, JR Weng, CW Shu* (2019)”Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells” Toxins 11, 313. (IF: 3.895, 19/135, FOOD SCIENCE & TECHNOLOGY)

5.  HY Chang, YK Tseng, YC Chen, CW Shu, MI Lin, HH Liou, TY Fu, YC Lin, LP Ger, MH Yeh, PF Liu*(2018) “High Snail Expression Predicts a Poor Prognosis in Breast Invasive Ductal Carcinoma Patients with HER2/EGFR-positive Subtypes” Surgical Oncology-Oxford 27, 314-320. (IF:3.000, 46/203, SURGERY)

6.PF Liu, KL Tsai, CJ Hsu, WL Tsai, JS Cheng, HW Chang, CW Shiau, YG Goan, HH Tseng, CH Wu, JC Reed, LW Yang, CW Shu* (2018) “Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy” Theranostics 8(3): 830-845. (IF: 8.063, 10/136, MEDICINE, RESEARCH & EXPERIMENTAL)

7.PF Liu, Y Wang, CM Huang*, RG Ulrich, CW. Simmons, JS. VanderGheynst, RL Gallo (2018) “Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves” Journal of Immunology Research 2018:3710961. (IF: 3.404, 73/158, IMMUNOLOGY)

8.   PF Liu, HW Chang, JS Cheng, HP Lee, CY Yen, WL Tsai, JT Cheng, YJ Li, WC Huang, CH Lee, LP Ger, CW Shu* (2018) “MAPLC3B and SQSTM1 Modulated Autophagy for Tumorigenesis and Prognosis in Certain Subsites of Oral Squamous Cell Carcinoma” Journal of Clinical Medicine 7(12), pii: E478. (IF: 5.688, 15/160, MEDICINE, GENERAL & INTERNAL)

9.  YD Tony Tzeng^#, PF Liu^# (co-first author), JY Li, LF Liu, SY Kuo, CW Hsieh, CH Lee, CH Wu, M Hsiao, HT Chang, CW Shu* (2018) “Kinome-wide siRNA Screening Identifies Src-enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells” Frontiers in Pharmacology 2018; 9:1285. (IF:3.845, 59/267, PHARMACOLOGY & PHARMACY)

10.  PF Liu, CJ Hsu, WL Tsai, JS Cheng, JJ Chen, IF Huang, HH Tseng, HW Chang, CW Shu* (2017) “Ablation of ATG4B Suppressed Autophagy and Activated AMPK for Cell Cycle Arrest in Cancer Cells” Cellular Physiology and Biochemistry 44:728-740. (IF:5.500, 8/83, PHYSIOLOGY).

11.  PF Liu, YC Hu, BH Kang, YK Tseng, PC Wu, CC Liang, YY Hou, TY Fu, HH Liou, IC Hsieh, LP Ger*, CW Shu*(2017) “Expression Levels of Cleaved Caspase-3 and Caspase-3 in Tumorigenesis and Prognosis of Oral Tongue Squamous Cell Carcinoma “PLoS One 12(7):e0180620. (IF:2.776, 15/64, MULTIDISCIPLINARY SCIENCES)

12.  PF Liu, BH Kang, YM Wu, JH Sun, LM Yen, TY Fu, YC Lin, HH Liou, YS Lin, HC Sie, IC Hsieh, YK Tseng, CW Shu, YD Hsieh, LP Ger* (2017) “Vimentin is a Potential Prognostic Factor for Tongue Squamous Cell Carcinoma among Five Epithelial–mesenchymal Transition-related Proteins “PLoS One 12(6):e0178581. (IF:2.776, 15/64, MULTIDISCIPLINARY SCIENCES)

13.  PF Liu, Y Wang, YT Liu, CM Huang* (2017). “Vaccination with Killed but Metabolically Active E. coli Over-expressing Hemagglutinin Elicits Neutralizing Antibodies to H1N1 Swine Origin Influenza A Virus” Journal of Nature and Science. 3(2) pii:e317. (IF: 2.37)

14.  Huang JS ^#, Yang CM ^# (co-equal first author), Wang JS, Liou HH, Hsieh IC, Li GC, Huang SJ, Shu CW, Fu TY, Lin YC, Ger LP, PF Liu* (2017) ” Caspase-3 Expression in Tumorigenesis and Prognosis of Buccal Mucosa Squamous Cell Carcinoma” Oncotarget 8(48):84237-84247. (2016 IF: 5.168, 44/217, ONCOLOGY)

15.  HH Tseng, YK Tseng, JJ You, BH Kang, TH Wang, CM Yang, HC Chen, HH Liou, PF Liu, LP Ger*, KW Tsai* (2017) “Next-generation Sequencing for microRNA Profiling: MicroRNA-21-3p Promotes Oral Cancer Metastasis” Anticancer Research 37(3):1059-1066. (IF: 1.935, 184/229, ONCOLOGY)

16.  TY Fu^#, CN Wu^#, HC Sie, JT Cheng, YS Lin, HH Liou, YK Tseng, CW Shu, KW Tsai, LM Yen, HW Tseng, CJ Tseng, LP Ger*, PF Liu* (2016) “Subsite-specific Association of DEAD Box RNA Helicase DDX60 with the Development and Prognosis of Oral Squamous Cell Carcinoma” Oncotarget 7(51):85097-85108. (2016 IF: 5.168, 44/217, ONCOLOGY)

17.  CW Shu, HT Chang, CS Wu, CH Chen, S Wu, Chang HW, Kuo SY, Fu E, PF Liu*, Hsieh YD (2016) “RelA-mediated BECN1 Expression is Required for Reactive Oxygen Species-Induced Autophagy in Oral Cancer Cells Exposed to Low-Power Laser Irradiation” PLoS One 11(9):e0160586. (IF:2.776, 15/64, MULTIDISCIPLINARY SCIENCES)

18.  HW Chen, PF Liu, YT Liu, S Kuo, XQ Zhang, RT Schooley, H Rohde, RL Gallo, CM Huang* (2016) “Nasal Commensal Staphylococcus Epidermidis Counteracts Influenza Virus”. Scientific Reports 6:27870. (SCI, IF: 4.011, 15/69,MULTIDISCIPLINARY SCIENCES)

19.  CM Yang, TH Wang, HC Chen, SC Li, MC Lee, HH Liou, PF Liu, YK Tseng, YL Shiue, LP Ger, KW Tsai* “Aberrant DNA Hypermethylation-silenced SOX21-AS1 Gene Expression and Its Clinical Importance in Oral Cancer “(2016) Clinical Epigenetics 8:129. (IF: 5.496, 21/174,GENETICS &HEREDITY)

20.  YY Ho, JJ You, CM Yang, HW Pan, HC Chen, JH Lee, YS Lin, HH Liou, PF Liu, LP Ger*, KW Tsai*. (2016) “Aberrant DNA Hypomethylation of miR-196b Gene Contributes to Migration and Invasion of Oral Cancer” Oncology Letters 11: 4013-4021. (IF: 1.871, 186/229, ONCOLOGY)

21.  PF Liu, JS Cheng, CL Sy, WC Huang, HC Yang, RL. Gallo, CM Huang, CW Shu* (2015) “IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureus” Journal of Investigative Dermatology 135(11):2714-2722. (IF: 6.290, 4/66, DERMATOLOGY). 

22.  PF Liu, YD Hsieh, YC Lin, A Two, CW Shu*, CM Huang* (2015) “Propionibacterium acnes in the Pathogenesis and Immunotherapy of Acne Vulgaris” Current Drug Metabolism 16(4):245-254. (IF: 2.277, 158/267, PHARMACOLOGY & PHARMACY)  

23.  WZ Liang^#, PF Liu^# (co-first author), E Fu, HS Chung, C-R Jan, CH Wu, CW Shu*, YD Hsieh* (2015) “Selective Cytotoxic Effects of Low-Power Laser Irradiation on Human Oral Cancer Cells” Lasers in Surgery and Medicine 47(9):756-764. (IF: 3.262, 37/203, SURGERY)  

24.  IF Huang^#, IC Lin^#, PF Liu, YC Liu, YD Hsieh, JJ Chen,CL Chen, HW Chang, CW Shu* (2015) “Lactobacillus Acidophilus Attenuates Salmonella-induced Intestinal inflammation via TGF-β signaling” BMC Microbiology 15(1):203. (IF: 3.287, 49/133, MICROBIOLOGY)  

25.  PF Liu, CM Leung, YH Chang, JS Cheng, JJ Chen, CJWeng, KW Tsai, CJ Hsu, YC Liu, PC Hsu, HW Pan, CW Shu* (2014) “ATG4B Promotes Colorectal Cancer Growth Independent of Autophagic Flux”Autophagy 10(8):1454-1465. (IF: 11.059, 14/193, CELL BIOLOGY)  

26.  PF Liu, IF Huang, CW Shu*, CM Huang* (2013) “Halitosis Vaccines Targeting FomA, a Biofilm-bridging Protein in Fusobacteria nucleatum” Current Molecular Medicine 13(8):1358-1367. (IF: 2.196, 84/136, MEDICINE, RESEARCH & EXPERIMENTAL)  

27.  WS Chen, TW Chen, TH Yang, LY Hu, HW Pan, CM Leung, SC Li, MR Ho, CW Shu, PF Liu, SY Yu, YT Tu, WC Lin, TT Wu*, KW Tsai* (2013)“Co-modulated Behavior and Effects of Differentially Expressed miRNA in Colorectal Cancer”BMC Genomics 14 (Suppl 5):S12. (SCI, IF: 3.501, 48/162, BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

28.  CW Shu*, PF Liu, CM Huang* (2012) ”High-Throughput Screening for Drug Discovery of Autophagy Modulators” Combinatorial Chemistry & High Throughput Screening 15(9):721-729. (SCI, IF: 1.503,39/71, CHEMISTRY, APPLIED)

29.  PF Liu, T Nakatsuji, W Zhu, RL Gallo, CM Huang* (2011) “Passive Immunoprotection Targeting a Secreted CAMP Factor of Propionibacterium acnes as a Novel Immunotherapeutic for Acne Vulgaris”Vaccine 29(17), 3230-3238. (IF:3.269, 57/136, MEDICINE, RESEARCH & EXPERIMENTAL)

30.  PF Liu, WY Shi, WH Zhu, JW Smith, SL Hsieh, RL Gallo, CM Huang* (2010) “Vaccination Targeting Surface FomA of Fusobacterium nucleatum against Bacterial Co-Aggregation: Implication for Treatment of Periodontal Infection and Halitosis” Vaccine 28(19), 3496-3505. (IF: 3.269, 57/136, MEDICINE, RESEARCH & EXPERIMENTAL)

31.  CHs Chen, XQ Zhang, CW Lo, PF Liu, YT Liu, RL Gallo, MF Hsieh*, RT Schooley*, CM Huang* (2010) “The Essentiality of Alpha-2-Macroglobulin in Human Salivary Innate Immunity against New H1N1 Swine Origin Influenza A Virus” Proteomics 10(12), 2396-2401. (IF: 3.106, 24/79, BIOCHEMICAL RESEARCH METHODS)

32.  YK Wang, WC Chang, PF Liu, MK Hsiao, CT Lin, SM Lin, RL Pan* (2010) “Ovate Family Protein 1 as A Plant Ku70 Interacting Protein Involving in DNA Double-Strand Break Repair” Plant Molecular Biology 74(4-5), 453-466. (IF: 3.928, 24/228, PLANT SCIENCES)

33.  PF Liu, WH Zhu, CM Huang* (2009) “Vaccines and Photodynamic Therapies for Oral Microbial-Related Diseases” Current Drug Metabolism 10(1), 90-94. (IF: 2.277, 158/267, PHARMACOLOGY & PHARMACY)  

34.  PF Liu, SK Haake, RL. Gallo, CM Huang* (2009) “A Novel Vaccine Targeting Fusobacterium nucleatum against Abscesses and Halitosis” Vaccine 27(10), 1589-1595. (2018 IF: 3.269, 57/136, MEDICINE, RESEARCH & EXPERIMENTAL)

35.  PF Liu, CW Lo, CH Chen, MF Hsien, CM Huang* (2009) “Use of Nanoparticles as Therapy for Methicillin-Resistant Staphylococcus aureus Infections” Current Drug Metabolism 10 (8), 875-884. (IF: 2.277, 158/267, PHARMACOLOGY & PHARMACY)  

36.  SH Hsu, YY Hsiao, PF Liu, SM Lin, YY Luo, RL Pan* (2009) “Purification, Characterization, and Spectral Analyses of Histidine-Tagged Vacuolar H+-Pyrophosphatase Expressed in Yeast”Botanical Studies 50, 291-301. (IF: 1.796, 95/228, PLANT SCIENCES)

37.  PF Liu, YK Wang, WC Chang, HY Chang, RL Pan* (2008) “Regulation of Arabidopsis thaliana Ku Genes at Different Developmental Stages under Heat Stress” Biochimica et Biophysica Acta- Gene Regulatory Mechanisms 1779 (6-7), 402-407. (IF: 4.599, 8/72, BIOPHYSICS)

38.  PF Liu, WC Chang, YK Wang, HY Chang, RL Pan* (2008) “Signaling Pathways Mediating the Suppression of Arabidopsis thaliana Ku Gene Expression by Abscisic Acid” Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 1779(3), 164-174. (IF: 4.599, 8/72, BIOPHYSICS)

39.  JY Fang, PF Liu, CM Huang* (2008) “Decreasing Systemic Toxicity via Transdermal Delivery of Anticancer Drugs” Current Drug Metabolism 9(7), 592-597. (IF: 2.655, 122/261, PHARMACOLOGY & PHARMACY)

40.  CW Shu, FC Sun, JH Cho, CC Lin, PF Liu, PY Chen, MDT Chang, HW Fu, YK Lai* (2008) “GRP78 and Raf-1 Cooperatively Confer Resistance to Endoplasmic Reticulum Stress-Induced Apoptosis” Journal of Cellular Physiology 215, 627-635. (IF: 4.522, 11/81, PHYSIOLOGY)

41.  WC Chang^#, YK Wang^#, PF Liu, YF Tsai, LR Kong, CK Lin, CH Yang, RL Pan* (2008) “Regulation of Ku Gene Promoters in Arabidopsis by Hormones and Stress.” Functional Plant Biology 35, 265-280. (IF: 2.327, 73/228, PLANT SCIENCE)

42.  PF Liu, WC Chang, YK Wang, SB Munisamy, SH Hsu, HY Chang, SH Wu, RL Pan* (2007)“Differential regulation of Ku gene expression in etiolated mung bean hypocotyls by auxins” Biochimica et Biophysica Acta- Gene Regulatory Mechanisms 1769(7-8), 443-454. (IF: 4.599, 8/72, BIOPHYSICS)

43.  Hsiao YY, Pan YJ, Hsu SH, Huang YT, Liu TH, Lee CH, Lee CH, Liu PF, Chang WC, Wang YK, Chien LF, Pan RL* (2007)” Functional roles of arginine residues in mung bean vacuolar H+-pyrophosphatase” Biochimica et Biophysica Acta- Bioenergetics 1767, 965-973. (IF: 4.441, 11/72, BIOPHYSICS)

44.  SY Kuo, LF Chien, RC Van, KH Yan, PF Liu, WC Chang, JK Wang, RL Pan* (2005) “Purification and Subunit Determination of H+-Pyrophosphatase from Endoplasmic Reticulum-Enriched Vesicles of Mung Bean Seedlings” Plant Science 169, 847-853. (IF: 3.785, 28/228, PLANT SCIENCES)

45.  SY Kuo, LF Chien, YY Hsiao, RC Van, KH Yan, PF Liu, SJ Mao, RL Pan* (2005) “Proton Pumping Inorganic Pyrophosphatase of Endoplasmic Reticulum-Enriched Vesicles from Etiolated Mung Bean eedlings.” Journal of Plant Physiology 162, 129-138. (IF: 2.825, 55/228, PLANT SCIENCES)

46.  KH Yan, PF Liu, HT Tzeng, WC Chang, WG Chou, RL Pan* (2004) “Characterization of DNA End-Binding Activities in Higher Plants” Plant Physiology and Biochemistry 42, 617-622. (IF: 3.404, 38/228, PLANT SCIENCES)