Assistant Professor Liu, Pei-Feng
Tel:+886-7-3121101 ext 2694
Email:pfliu@kmu.edu.tw
Expertise:Cancer Biology, Bacterial infection, Biomarker screening, Clinical data analysis, Immunohistochemistry, Target therapy and vaccine development
Education&Experience
Education:
Ph.D. Department of Life Science, National Tsing-Hua University
Experience:
Teaching
•Assistant Professor-Department of Biomedical Science and Environment Biology, Kaohsiung Medical University (108.08-present)
•Jointly Appointed Assistant Professor-Institute of Biomedical Sciences, National Sun Yat-sen University (108.02-present)
•Adjunct Assistant Professor-Shu-Zen Junior College of Medicine and Management
•Adjunct Assistant Professor-Department of Biotechnology, Fooyin University
Research
•Senior Assistant Research Fellow-Department of Medical Education and Research, Kaohsiung Veterans General Hospital
•Postdoctoral Fellow-Department of Medical Education and Research, Kaohsiung Veterans General Hospital
•Post-doctoral Fellow-Department of Medical Research, Kaohsiung Medical University
•Visiting Scientist-Sanford-Burnham Medical Research Institute, San Diego, CA, USA
•Post-doctoral Fellow-School of Medicine, University of California, San Diego, USA/Veterans Medical Research Foundation
Teaching
Courses Offered:
Molecular Biology, Cell Biology, General Biology (Including Laboratory), Molecular Biotechnology. Molecular Oncology
Specialty & Research Interests
Specialty:
Cancer biology, Bacterial infectious diseases, Molecular biology, Cell biology, Clinical data analysis, Immunohistochemistry analysis, Biomarker screening and identification, Development of therapeutic targets.
Research Interests:
Screening biomarkers of cancers and infectious diseases to (1) investigate their molecular mechanisms; (2) identify their potential roles in diagnosis, prognosis and targeted therapy.
Publications
Publications:(#: first author; *: corresponding author)
1.PF Liu*, HC Chen, CW Shu, HC Sie, CH Lee, HH Liou, JT Cheng, KW Tsai, LP Ger (2020)
Guanylate-binding Protein 6 is a Novel Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma. Clinical Oral Investigations (IF:2.812, 15/91, DENTISTRY, ORAL, SURGERY &MEDICINE)
2.HC Chen#, YK Tseng#, CW Shu, TY Fu, HH Liou, CH Huang, CC Chen, JS Wang, PC Wu, LP Ger, WC Hung, PF Liu* (2020) Prognostic Role of RECK in Pathological Outcome-dependent Buccal Mucosa Squamous Cell Carcinoma. Oral Diseases 2020;26:62-71. (IF:2.613, 19/91, DENTISTRY, ORAL, SURGERY &MEDICINE)
3.BH Kang#, CW Shu#, JK Chao, CH Lee, TY Fu, HH Liou, LP Ger, PF Liu* (2020) HSPD1 Repressed E-cadherin Expression to Promote Cell Invasion and Migration for Poor Prognosis in Oral Squamous Cell Carcinoma. Scientific Reports 10(1):1829 (IF: 3.998, 17/71, MULTIDISCIPLINARY SCIENCES)
4.PF Liu, HC Chen, JS Cheng, WL Tsai, HP Lee, SC Wang, WH Peng, CH Lee, LP Ger, CW Shu* (2019) Association of ATG4B and Phosphorylated ATG4B Proteins with Tumorigenesis and Prognosis in Oral Squamous Cell Carcinoma. Cancers (Basel) 11(12). pii: E1854 (IF: 6.126, 37/244, ONCOLOGY)
5.YG Goan, PF Liu, HW Chang, HC Chen, WC Chen, SM Kuo, CH Lee, CW Shu* (2019) Kinome-Wide Screening with Small Interfering RNA Identified Polo-like Kinase 1 as a Key Regulator of Proliferation in Oral Cancer Cells. Cancers (Basel) 11(8). pii: E1117 (IF: 6.126, 37/244, ONCOLOGY)
6.HC Chen#, YK Tseng#, CW Shu, TJ Weng, HH Liou, LM Yen, IC Hsieh, CC Wang, PC Wu, YL Shiue, TY Fu, KW Tsai, LP Ger*, PF Liu*(2019) Differential Clinical Significance of COL5A1 and COL5A2 in Tongue Squamous Cell Carcinoma. Journal of Oral Pathology & Medicine 48(6):468-476 (IF: 2.495, 20/91, DENTISTRY, ORAL, SURGERY &MEDICINE)
7.JS Cheng#, WL Tsai#, PF Liu# (co-first author), YG Goan, CW Lin, HH Tseng, CH Lee, CW Shu* (2019) The MAP3K7-mTOR Axis Promotes the Proliferation and Malignancy of Hepatocellular Carcinoma Cells. Frontiers in Oncology 9:474 (IF: 4.848, 69/244, ONCOLOGY)
8.HW Chang#, PF Liu# (co-first author), WL Tsai, WH Hu, YC Hu, HC Yang, WY Lin, JR Weng, CW Shu* (2019) Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells. Toxins 11, 313 (IF: 3.531, 21/92, TOXICOLOGY)
9.HY Chang, YK Tseng, YC Chen, CW Shu, MI Lin, HH Liou, TY Fu, YC Lin, LP Ger, MH Yeh*, PF Liu*(2018) High Snail Expression Predicts a Poor Prognosis in Breast Invasive Ductal Carcinoma Patients with HER2/EGFR-positive Subtypes. Surgical Oncology-Oxford 27, 314-320 (IF:2.521, 68/210, SURGERY)
10.PF Liu#, KL Tsai#, CJ Hsu#, WL Tsai, JS Cheng, HW Chang, CW Shiau, YG Goan, HH Tseng, CH Wu, JC Reed, LW Yang, CW Shu* (2018) Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy. Theranostics 8(3): 830-845 (IF: 8.579, 10/138, MEDICINE, RESEARCH & EXPERIMENTAL)
11.PF Liu, Y Wang, RG Ulrich, CW. Simmons, JS. VanderGheynst, RL Gallo, CM Huang* (2018) Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves. Journal of Immunology Research 2018:3710961 (IF: 3.327, 80/158, IMMUNOLOGY)
12.PF Liu#, HW Chang#, JS Cheng, HP Lee, CY Yen, WL Tsai, JT Cheng, YJ Li, WC Huang, CH Lee, LP Ger, CW Shu* (2018) MAPLC3B and SQSTM1 Modulated Autophagy for Tumorigenesis and Prognosis in Certain Subsites of Oral Squamous Cell Carcinoma. Journal of Clinical Medicine 7(12), pii: E478 (IF: 3.303, 36/165, MEDICINE, GENERAL & INTERNAL)
13.YD Tony Tzeng#, PF Liu# (co-first author), JY Li, LF Liu, SY Kuo, CW Hsieh, CH Lee, CH Wu, M Hsiao, HT Chang, CW Shu* (2018) Kinome-wide siRNA Screening Identifies Src-enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells. Frontiers in Pharmacology 2018; 9:1285 (IF: 4.225, 52/270, PHARMACOLOGY & PHARMACY)
14.PF Liu#, CJ Hsu#, WL Tsai, JS Cheng, JJ Chen, IF Huang, HH Tseng, HW Chang*, CW Shu* (2017) Ablation of ATG4B Suppressed Autophagy and Activated AMPK for Cell Cycle Arrest in Cancer Cells. Cellular Physiology and Biochemistry 44:728-740 (2017 IF:5.500, 8/83, PHYSIOLOGY).
15.PF Liu, YC Hu, BH Kang, YK Tseng, PC Wu, CC Liang, YY Hou, TY Fu, HH Liou, IC Hsieh, LP Ger*, CW Shu*(2017) Expression Levels of Cleaved Caspase-3 and Caspase-3 in Tumorigenesis and Prognosis of Oral Tongue Squamous Cell Carcinoma. PLoS One 12(7):e0180620 (IF: 2.740, 27/71, MULTIDISCIPLINARY SCIENCES)
16.PF Liu#, BH Kang#, YM Wu, JH Sun, LM Yen, TY Fu, YC Lin, HH Liou, YS Lin, HC Sie, IC Hsieh, YK Tseng, CW Shu, YD Hsieh, LP Ger* (2017) Vimentin is a Potential Prognostic Factor for Tongue Squamous Cell Carcinoma among Five Epithelial–mesenchymal Transition-related Proteins. PLoS One 12(6):e0178581 (IF: 2.740, 27/71, MULTIDISCIPLINARY SCIENCES)
17.PF Liu, Y Wang, YT Liu, CM Huang* (2017) Vaccination with Killed but Metabolically Active E. coli Over-expressing Hemagglutinin Elicits Neutralizing Antibodies to H1N1 Swine Origin Influenza A Virus. Journal of Nature and Science 3(2) pii: e317 (IF: 2.37)
18.Huang JS#, Yang CM# (co-equal first author), Wang JS, Liou HH, Hsieh IC, Li GC, Huang SJ, Shu CW, Fu TY, Lin YC, Ger LP*, PF Liu* (2017) Caspase-3 Expression in Tumorigenesis and Prognosis of Buccal Mucosa Squamous Cell Carcinoma. Oncotarget 8(48):84237-84247 (2016 IF: 5.168, 44/217, ONCOLOGY)
19.HH Tseng, YK Tseng, JJ You, BH Kang, TH Wang, CM Yang, HC Chen, HH Liou, PF Liu, LP Ger*, KW Tsai* (2017) Next-generation Sequencing for microRNA Profiling: MicroRNA-21-3p Promotes Oral Cancer Metastasis. Anticancer Research 37(3):1059-1066 (IF: 1.994, 203/224, ONCOLOGY)
20.TY Fu#, CN Wu#, HC Sie, JT Cheng, YS Lin, HH Liou, YK Tseng, CW Shu, KW Tsai, LM Yen, HW Tseng, CJ Tseng, LP Ger*, PF Liu* (2016) Subsite-specific Association of DEAD Box RNA Helicase DDX60 with the Development and Prognosis of Oral Squamous Cell Carcinoma. Oncotarget 7(51):85097-85108 (2016 IF: 5.168, 44/217, ONCOLOGY)
21.CW Shu, HT Chang, CS Wu, CH Chen, S Wu, Chang HW, Kuo SY, Fu E, PF Liu* (co-corresponding author), Hsieh YD* (2016) RelA-mediated BECN1 Expression is Required for Reactive Oxygen Species-Induced Autophagy in Oral Cancer Cells Exposed to Low-Power Laser Irradiation. PLoS One 11(9):e0160586 (IF: 2.740, 27/71, MULTIDISCIPLINARY SCIENCES)
22.HW Chen, PF Liu, YT Liu, S Kuo, XQ Zhang, RT Schooley, H Rohde, RL Gallo, CM Huang* (2016)
Nasal Commensal Staphylococcus Epidermidis Counteracts Influenza Virus. Scientific Reports 6:27870 (SCI, IF: 3.998, 17/71, MULTIDISCIPLINARY SCIENCES)
23.CM Yang, TH Wang, HC Chen, SC Li, MC Lee, HH Liou, PF Liu, YK Tseng, YL Shiue, LP Ger, KW Tsai* (2016) Aberrant DNA Hypermethylation-silenced SOX21-AS1 Gene Expression and Its Clinical Importance in Oral Cancer. Clinical Epigenetics 8:129 (IF: 5.028, 29/177, GENETICS &HEREDITY)
24.YY Ho, JJ You, CM Yang, HW Pan, HC Chen, JH Lee, YS Lin, HH Liou, PF Liu, LP Ger*, KW Tsai*. (2016) Aberrant DNA Hypomethylation of miR-196b Gene Contributes to Migration and Invasion of Oral Cancer. Oncology Letters 11: 4013-4021 (IF: 2.311, 182/244, ONCOLOGY)
25.PF Liu#, JS Cheng#, CL Sy#, WC Huang, HC Yang, RL. Gallo, CM Huang, CW Shu* (2015) IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureus. Journal of Investigative Dermatology 135(11):2714-2722 (IF: 7.143, 3/68, DERMATOLOGY).
26.PF Liu, YD Hsieh, YC Lin, A Two, CW Shu*, CM Huang* (2015) Propionibacterium acnes in the Pathogenesis and Immunotherapy of Acne Vulgaris. Current Drug Metabolism 16(4):245-254 (IF: 2.960, 114/270, PHARMACOLOGY & PHARMACY)
27.WZ Liang#, PF Liu# (co-first author), E Fu, HS Chung, C-R Jan, CH Wu, CW Shu*, YD Hsieh* (2015) Selective Cytotoxic Effects of Low-Power Laser Irradiation on Human Oral Cancer Cells. Lasers in Surgery and Medicine 47(9):756-764 (IF: 3.020, 49/210, SURGERY)
28.IF Huang#, IC Lin#, PF Liu, YC Liu, YD Hsieh, JJ Chen, CL Chen, HW Chang, CW Shu* (2015) Lactobacillus Acidophilus Attenuates Salmonella-induced Intestinal inflammation via TGF-β signaling. BMC Microbiology 15(1):203 (IF: 2.989, 67/135, MICROBIOLOGY)
29.PF Liu#, CM Leung#, YH Chang, JS Cheng, JJ Chen, CJWeng, KW Tsai, CJ Hsu, YC Liu, PC Hsu, HW Pan*, CW Shu* (2014) ATG4B Promotes Colorectal Cancer Growth Independent of Autophagic Flux. Autophagy 10(8):1454-1465 (IF: 9.770, 22/195, CELL BIOLOGY)
30.PF Liu, IF Huang, CW Shu*, CM Huang* (2013) Halitosis Vaccines Targeting FomA, a Biofilm-bridging Protein in Fusobacteria nucleatum. Current Molecular Medicine 13(8):1358-1367 (IF: 1.600, 109/138, MEDICINE, RESEARCH & EXPERIMENTAL)
31.WS Chen, TW Chen, TH Yang, LY Hu, HW Pan, CM Leung, SC Li, MR Ho, CW Shu, PF Liu, SY Yu, YT Tu, WC Lin, TT Wu*, KW Tsai* (2013) Co-modulated Behavior and Effects of Differentially Expressed miRNA in Colorectal Cancer. BMC Genomics 14 (Suppl 5):S12 (SCI, IF: 3.594, 43/156, BIOTECHNOLOGY & APPLIED MICROBIOLOGY)
32.CW Shu*, PF Liu, CM Huang* (2012) High-Throughput Screening for Drug Discovery of Autophagy Modulators. Combinatorial Chemistry & High Throughput Screening 15(9):721-729 (SCI, IF:1.195,49/71, CHEMISTRY, APPLIED)
33.PF Liu, T Nakatsuji, W Zhu, RL Gallo, CM Huang* (2011) Passive Immunoprotection Targeting a Secreted CAMP Factor of Propionibacterium acnes as a Novel Immunotherapeutic for Acne Vulgaris. Vaccine 29(17), 3230-3238 (IF:3.143, 68/138, MEDICINE, RESEARCH & EXPERIMENTAL)
34.PF Liu, WY Shi, WH Zhu, JW Smith, SL Hsieh, RL Gallo, CM Huang* (2010) Vaccination Targeting Surface FomA of Fusobacterium nucleatum against Bacterial Co-Aggregation: Implication for Treatment of Periodontal Infection and Halitosis. Vaccine 28(19), 3496-3505 (IF: 3.143, 68/138, MEDICINE, RESEARCH & EXPERIMENTAL)
35.CHs Chen, XQ Zhang, CW Lo, PF Liu, YT Liu, RL Gallo, MF Hsieh*, RT Schooley*, CM Huang* (2010) The Essentiality of Alpha-2-Macroglobulin in Human Salivary Innate Immunity against New H1N1 Swine Origin Influenza A Virus. Proteomics 10(12), 2396-2401 (IF: 3.254, 23/77, BIOCHEMICAL RESEARCH METHODS)
36.YK Wang, WC Chang, PF Liu, MK Hsiao, CT Lin, SM Lin, RL Pan* (2010) Ovate Family Protein 1 as A Plant Ku70 Interacting Protein Involving in DNA Double-Strand Break Repair. Plant Molecular Biology 74(4-5), 453-466 (IF: 3.302, 42/234, PLANT SCIENCES)
37.PF Liu, WH Zhu, CM Huang* (2009) Vaccines and Photodynamic Therapies for Oral Microbial-Related Diseases. Current Drug Metabolism 10(1), 90-94 (IF: 2.960, 114/270, PHARMACOLOGY & PHARMACY)
38.PF Liu, SK Haake, RL. Gallo, CM Huang* (2009) A Novel Vaccine Targeting Fusobacterium nucleatum against Abscesses and Halitosis. Vaccine 27(10), 1589-1595 (IF: 3.143, 68/138, MEDICINE, RESEARCH & EXPERIMENTAL)
39.PF Liu, CW Lo, CH Chen, MF Hsien, CM Huang* (2009) Use of Nanoparticles as Therapy for Methicillin-Resistant Staphylococcus aureus Infections. Current Drug Metabolism 10 (8), 875-884. (IF: 2.960, 114/270, PHARMACOLOGY & PHARMACY)
40.SH Hsu, YY Hsiao, PF Liu, SM Lin, YY Luo, RL Pan* (2009) Purification, Characterization, and Spectral Analyses of Histidine-Tagged Vacuolar H+-Pyrophosphatase Expressed in Yeast. Botanical Studies 50, 291-301 (IF: 2.163, 83/234, PLANT SCIENCES)
41.PF Liu, YK Wang, WC Chang, HY Chang, RL Pan* (2008) Regulation of Arabidopsis thaliana Ku Genes at Different Developmental Stages under Heat Stress. Biochimica et Biophysica Acta- Gene Regulatory Mechanisms 1779 (6-7), 402-407 (IF: 3.510, 17/71, BIOPHYSICS)
42.PF Liu, WC Chang, YK Wang, HY Chang, RL Pan* (2008) Signaling Pathways Mediating the Suppression of Arabidopsis thaliana Ku Gene Expression by Abscisic Acid. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 1779(3), 164-174 (IF: 3.510, 17/71, BIOPHYSICS)
43.JY Fang, PF Liu, CM Huang* (2008) Decreasing Systemic Toxicity via Transdermal Delivery of Anticancer Drugs. Current Drug Metabolism 9(7), 592-597 (IF: 2.960, 114/270, PHARMACOLOGY & PHARMACY)
44.CW Shu, FC Sun, JH Cho, CC Lin, PF Liu, PY Chen, MDT Chang, HW Fu, YK Lai* (2008) GRP78 and Raf-1 Cooperatively Confer Resistance to Endoplasmic Reticulum Stress-Induced Apoptosis. Journal of Cellular Physiology 215, 627-635 (IF: 5.546, 7/81, PHYSIOLOGY)
45.WC Chang#, YK Wang#, PF Liu, YF Tsai, LR Kong, CK Lin, CH Yang, RL Pan* (2008) Regulation of Ku Gene Promoters in Arabidopsis by Hormones and Stress. Functional Plant Biology 35, 265-280 (IF: 2.617, 64/234, PLANT SCIENCE)
46.PF Liu, WC Chang, YK Wang, SB Munisamy, SH Hsu, HY Chang, SH Wu, RL Pan* (2007) Differential regulation of Ku gene expression in etiolated mung bean hypocotyls by auxins. Biochimica et Biophysica Acta- Gene Regulatory Mechanisms 1769(7-8), 443-454 (IF: 3.510, 17/71, BIOPHYSICS)
47.YY Hsiao, YJ Pan, SH Hsu, YT Huang, TH Liu, CH Lee, CH Lee, PF Liu, WC Chang, YK Wang, LF Chien, RL Pan * (2007) Functional roles of arginine residues in mung bean vacuolar H+-pyrophosphatase. Biochimica et Biophysica Acta- Bioenergetics 1767, 965-973 (IF: 3.465, 18/71, BIOPHYSICS)
48.SY Kuo, LF Chien, RC Van, KH Yan, PF Liu, WC Chang, JK Wang, RL Pan* (2005) Purification and Subunit Determination of H+-Pyrophosphatase from Endoplasmic Reticulum-Enriched Vesicles of Mung Bean Seedlings. Plant Science 169, 847-853 (IF: 3.591, 37/234, PLANT SCIENCES)
49.SY Kuo, LF Chien, YY Hsiao, RC Van, KH Yan, PF Liu, SJ Mao, RL Pan* (2005) Proton Pumping Inorganic Pyrophosphatase of Endoplasmic Reticulum-Enriched Vesicles from Etiolated Mung Bean eedlings. Journal of Plant Physiology 162, 129-138 (IF: 3.013, 49/234, PLANT SCIENCES)
50.KH Yan, PF Liu, HT Tzeng, WC Chang, WG Chou, RL Pan* (2004) Characterization of DNA End-Binding Activities in Higher Plants. Plant Physiology and Biochemistry 42, 617-622 (IF: 3.720, 33/234, PLANT SCIENCES)
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