Teaching

Teaching:

Molecular Biology, Cell Biology, General Biology (Including Laboratory), Molecular Biotechnology, Molecular Oncology

Specialty & Research Interests

Specialty:

Cancer, Bacterial infectious diseases, Molecular biology, Cell biology, Clinical data analysis, Immunohistochemistry analysis, Screening biomarkers, Developing therapeutic targets.

 

Research Interests:

Screening biomarkers of cancers and infectious diseases to (1) investigate their molecular mechanisms; (2) identify their potential roles in diagnosis, prognosis and targeted therapy.

 

Honors

Honors:

• Instructing undergraduate students for outstanding poster  presentation award in College of Life Science-Kaohsiung Medical University (109 Semester, 2021)

• Instructing graduate students for outstanding poster presentation award in College of Life Science-Kaohsiung Medical University (109 Semester, 2021)

• Instructing summer undergraduate students for outstanding poster presentation award-Kaohsiung Medical University (109 Semester, 2020)

• Outstanding Course Evaluation-Kaohsiung Medical University (108 Semester, 2020)

• Outstanding Teaching Award-Kaohsiung Medical University (108 Semester, 2020)

• Outstanding Student Mentoring in College of Life Science-Kaohsiung Medical University (108 Semester, 2020)

• Outstanding Paper Award-Kaohsiung Medical University (108 Semester, 2019)

• Young research scholarship-Yen Tjing Ling Medical Foundation (2018)

 

Publications

Publications: (^#: first author; *: corresponding author)

 1.     PF Liu, CW Shu, CH Lee, HC Sie, HH Liou, JT Cheng, LP Ger, CL Chen, CC Chen^*, CF Chen^* (2021) Clinical Significance and the Role of Guanylate-Binding Protein 5 in Oral Squamous Cell Carcinoma. Cancers (Basel) 13(16): 4043. (IF: 6.639, 51/242, ONCOLOGY)

2.      CW Shu^#, JR Weng^#, HW Chang, PF Liu, JJ Chen, CC Peng, JW Huang, WY Lin, CY Yen^* (2021) Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells. Environmental Toxicology 36:1173–1180. (IF: 4.119, 21/98, WATER RESOURCES)

3.      WH Hu^#, WC Yang^#, PF Liu, TT Liu, P Morgan, WL Tsai, HW Pan, CH Lee CW Shu^* (2021) Clinicopathological Association of Autophagy Related 5 Protein with Prognosis of Colorectal Cancer. Diagnostics 2021, 11, 782. (IF: 3.706, 45/169, MEDICINE, GENERAL & INTERNAL)

4.      CY Huang^#, CL Chung^#, TH Hu, JJ Chen, PF Liu, CL Chen^* (2021) Recent progress in TGF-β inhibitors for cancer therapy. Biomedicine & Pharmacotherapy 134:111046. (IF: 6.529, 25/275, PHARMACOLOGY & PHARMACY)

5.      JT Cheng^#, PF Liu^#(co-first author), HC Yang, SJ Huang, M Griffithg, P Morgang, CW Shu^* (2021) Tumor Susceptibility Gene 101 facilitates rapamycin-induced autophagic flux in neuron cells. Biomedicine & Pharmacotherapy 134:111106. (IF: 6.529, 25/275, PHARMACOLOGY & PHARMACY)

6.      PF Liu^#, AA Farooqie^#, SY Peng, TJ Yu, HU Dahms, C H Lee, JY Tang, SC Wang, CW Shu*, HW Chang^* (2020) Regulatory effects of noncoding RNAs on the interplay of oxidative stress and autophagy in cancer malignancy and therapy. Seminars in Cancer Biology (In Press) (IF: 15.707, 12/242, ONCOLOGY)

7.      PF Liu, CF Chen, CW Shu, HM Chang, CH Lee, HH Liou, LP Ger, CL Chen, BH Kang^* (2020) UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma. Diagnostics 2020, 10, 674. (IF: 3.706, 45/169, MEDICINE, GENERAL & INTERNAL)

8.      PF Liu^*, HC Chen, CW Shu, HC Sie, CH Lee, HH Liou, JT Cheng, KW Tsai, LP Ger (2020) Guanylate-binding Protein 6 is a Novel Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma. Clinical Oral Investigations 24:2673–2682. (IF: 3.573, 21/91, DENTISTRY, ORAL, SURGERY &MEDICINE)

9.      HC Chen^#, YK Tseng^#, CW Shu, TY Fu, HH Liou, CH Huang, CC Chen, JS Wang, PC Wu, LP Ger, WC Hung, PF Liu^* (2020) Prognostic Role of RECK in Pathological Outcome-dependent Buccal Mucosa Squamous Cell Carcinoma. Oral Diseases 2020; 26:62-71. (IF: 3.511, 23/91, DENTISTRY, ORAL,   SURGERY &MEDICINE)

10.   BH Kang^#, CW Shu^#, JK Chao, CH Lee, TY Fu, HH Liou, LP Ger, PF Liu^* (2020) HSPD1 Repressed E-cadherin Expression to Promote Cell Invasion and Migration for Poor Prognosis in Oral Squamous Cell Carcinoma. Scientific Reports 10(1):1829 (IF: 4.379, 17/73, MULTIDISCIPLINARY SCIENCES)

11.   PF Liu, HC Chen, JS Cheng, WL Tsai, HP Lee, SC Wang, WH Peng, CH Lee, LP Ger, CW Shu^* (2019) Association of ATG4B and Phosphorylated ATG4B Proteins with Tumorigenesis and Prognosis in Oral Squamous Cell Carcinoma. Cancers (Basel) 11(12): 1854. (IF: 6.693, 51/242, ONCOLOGY)

12.   YG Goan, PF Liu, HW Chang, HC Chen, WC Chen, SM Kuo, CH Lee, CW Shu^* (2019) Kinome-Wide Screening with Small Interfering RNA Identified Polo-like Kinase 1 as a Key Regulator of Proliferation in Oral Cancer Cells. Cancers (Basel) 11(8):1117. (IF: 6.693, 51/242, ONCOLOGY)

13.   HC Chen^#, YK Tseng^#, CW Shu, TJ Weng, HH Liou, LM Yen, IC Hsieh, CC Wang, PC Wu, YL Shiue, TY Fu,KW Tsai, LP Ger*, PF Liu^*(2019) Differential Clinical Significance of COL5A1 and COL5A2 in Tongue Squamous Cell Carcinoma. Journal of Oral Pathology & Medicine 48(6):468-476 (IF: 4.253, 15/91, DENTISTRY, ORAL, SURGERY &MEDICINE)

14.   JS Cheng^#, WL Tsai^#, PF Liu^# (co-first author), YG Goan, CW Lin, HH Tseng, CH Lee, CW Shu^* (2019) The MAP3K7-mTOR Axis Promotes the Proliferation and Malignancy of Hepatocellular Carcinoma Cells.  Frontiers in Oncology 9:474 (IF: 6.244, 102/309, ONCOLOGY)

15.   HW Chang^#, PF Liu^# (co-first author), WL Tsai, WH Hu, YC Hu, HC Yang, WY Lin, JR Weng, CW Shu^* (2019) Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells. Toxins 11, 313 (IF: 4.546, 32/144, FOOD SCIENCE & TECHNOLOGY)

16.   HY Chang, YK Tseng, YC Chen, CW Shu, MI Lin, HH Liou, TY Fu, YC Lin, LP Ger, MH Yeh^*, PF Liu^*(2018) High Snail Expression Predicts a Poor Prognosis in Breast Invasive Ductal Carcinoma Patients with HER2/EGFR-positive Subtypes. Surgical Oncology-Oxford 27, 314-320 (IF: 3.279, 69/212, SURGERY)

17.   PF Liu^#, KL Tsai^#, CJ Hsu^#, WL Tsai, JS Cheng, HW Chang, CW Shiau, YG Goan, HH Tseng, CH Wu, JC Reed, LW Yang, CW Shu^* (2018) Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy. Theranostics 8(3): 830-845 (IF: 11.556, 9/140, MEDICINE, RESEARCH & EXPERIMENTAL)

18.   PF Liu, Y Wang, RG Ulrich, CW. Simmons, JS. VanderGheynst, RL Gallo, CM Huang^* (2018) Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves. Journal of Immunology Research 2018:3710961 (IF: 4.818, 65/162, IMMUNOLOGY)

19.   PF Liu^#, HW Chang^#, JS Cheng, HP Lee, CY Yen, WL Tsai, JT Cheng, YJ Li, WC Huang, CH Lee, LP Ger, CW Shu^* (2018) MAPLC3B and SQSTM1 Modulated Autophagy for Tumorigenesis and Prognosis in Certain Subsites of Oral Squamous Cell Carcinoma. Journal of Clinical Medicine 7(12): E478 (IF: 4.241, 35/315, MEDICINE, GENERAL & INTERNAL)

20.   YD Tony Tzeng^#, PF Liu^# (co-first author), JY Li, LF Liu, SY Kuo, CW Hsieh, CH Lee, CH Wu, M Hsiao, HT Chang, CW Shu^* (2018) Kinome-wide siRNA Screening Identifies Src-enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells. Frontiers in Pharmacology 2018; 9:1285 (IF: 5.810, 40/275, PHARMACOLOGY & PHARMACY)

21.   PF Liu^#, CJ Hsu^#, WL Tsai, JS Cheng, JJ Chen, IF Huang, HH Tseng, HW Chang*, CW Shu^* (2017) Ablation of ATG4B Suppressed Autophagy and Activated AMPK for Cell Cycle Arrest in Cancer Cells.  Cellular Physiology and Biochemistry 44:728-740 (2017 IF:5.500, 8/83, PHYSIOLOGY).

22.   PF Liu, YC Hu, BH Kang, YK Tseng, PC Wu, CC Liang, YY Hou, TY Fu, HH Liou, IC Hsieh, LP Ger*, CW Shu^*(2017) Expression Levels of Cleaved Caspase-3 and Caspase-3 in Tumorigenesis and Prognosis of Oral Tongue Squamous Cell Carcinoma. PLoS One 12(7):e0180620 (IF: 3.240, 26/73, MULTIDISCIPLINARY SCIENCES)

23.   PF Liu^#, BH Kang^#, YM Wu, JH Sun, LM Yen, TY Fu, YC Lin, HH Liou, YS Lin, HC Sie, IC Hsieh, YK Tseng, CW Shu, YD Hsieh, LP Ger^* (2017) Vimentin is a Potential Prognostic Factor for Tongue Squamous Cell Carcinoma among Five Epithelial–mesenchymal Transition-related Proteins. PLoS One 12(6):e0178581 (IF: 3.240, 26/73, MULTIDISCIPLINARY SCIENCES)

24.   PF Liu, Y Wang, YT Liu, CM Huang^* (2017) Vaccination with Killed but Metabolically Active E. coli Over-expressing Hemagglutinin Elicits Neutralizing Antibodies to H1N1 Swine Origin Influenza A Virus.  Journal of Nature and Science 3(2) pii: e317.

25.   Huang JS^#, Yang CM^# (co-equal first author), Wang JS, Liou HH, Hsieh IC, Li GC, Huang SJ, Shu CW, Fu TY, Lin YC, Ger LP^*, PF Liu^* (2017) Caspase-3 Expression in Tumorigenesis and Prognosis of Buccal Mucosa Squamous Cell Carcinoma. Oncotarget 8(48):84237-84247 (2016 IF: 5.168, 44/217, ONCOLOGY)

26.   HH Tseng, YK Tseng, JJ You, BH Kang, TH Wang, CM Yang, HC Chen, HH Liou, PF Liu, LP Ger^*, KW Tsai^* (2017) Next-generation Sequencing for microRNA Profiling: MicroRNA-21-3p Promotes Oral Cancer Metastasis. Anticancer Research 37(3):1059-1066 (IF: 2.480, 209/242, ONCOLOGY)

27.   TY Fu^#, CN Wu^#, HC Sie, JT Cheng, YS Lin, HH Liou, YK Tseng, CW Shu, KW Tsai, LM Yen, HW Tseng, CJ Tseng, LP Ger^*, PF Liu^* (2016) Subsite-specific Association of DEAD Box RNA Helicase DDX60 with the Development and Prognosis of Oral Squamous Cell Carcinoma. Oncotarget 7(51):85097-85108 (2016 IF: 5.168, 44/217, ONCOLOGY)

28.   CW Shu, HT Chang, CS Wu, CH Chen, S Wu, Chang HW, Kuo SY, Fu E, PF Liu^* (co-corresponding author), Hsieh YD^* (2016) RelA-mediated BECN1 Expression is Required for Reactive Oxygen Species-Induced Autophagy in Oral Cancer Cells Exposed to Low-Power Laser Irradiation. PLoS One 11(9):e0160586 (IF: 3.240, 26/73, MULTIDISCIPLINARY SCIENCES)

29.   HW Chen, PF Liu, YT Liu, S Kuo, XQ Zhang, RT Schooley, H Rohde, RL Gallo, CM Huang^* (2016) Nasal Commensal Staphylococcus Epidermidis Counteracts Influenza Virus. Scientific Reports 6:27870 (SCI, IF: 4.379, 17/73, MULTIDISCIPLINARY SCIENCES)

30.   CM Yang, TH Wang, HC Chen, SC Li, MC Lee, HH Liou, PF Liu, YK Tseng, YL Shiue, LP Ger, KW Tsai^* (2016) Aberrant DNA Hypermethylation-silenced SOX21-AS1 Gene Expression and Its Clinical Importance in Oral Cancer. Clinical Epigenetics 8:129 (IF: 6.551, 21/175, GENETICS &HEREDITY)

31.   YY Ho, JJ You, CM Yang, HW Pan, HC Chen, JH Lee, YS Lin, HH Liou, PF Liu, LP Ger^*, KW Tsai^*. (2016) Aberrant DNA Hypomethylation of miR-196b Gene Contributes to Migration and Invasion of Oral Cancer. Oncology Letters 11: 4013-4021 (IF: 2.967, 184/242, ONCOLOGY)

32.   PF Liu^#, JS Cheng^#, CL Sy^#, WC Huang, HC Yang, RL. Gallo, CM Huang, CW Shu^* (2015) IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureus. Journal of Investigative Dermatology 135(11):2714-2722 (IF: 8.551, 4/68, DERMATOLOGY).

33.   PF Liu, YD Hsieh, YC Lin, A Two, CW Shu*, CM Huang^* (2015) Propionibacterium acnes in the Pathogenesis and Immunotherapy of Acne Vulgaris. Current Drug Metabolism 16(4):245-254 (IF: 3.731, 125/275, PHARMACOLOGY & PHARMACY)

34.   WZ Liang^#, PF Liu^# (co-first author), E Fu, HS Chung, C-R Jan, CH Wu, CW Shu^*, YD Hsieh^* (2015) Selective Cytotoxic Effects of Low-Power Laser Irradiation on Human Oral Cancer Cells. Lasers in Surgery and Medicine 47(9):756-764 (IF: 4.025, 44/212, SURGERY)

35.   IF Huang^#, IC Lin^#, PF Liu, YC Liu, YD Hsieh, JJ Chen, CL Chen, HW Chang, CW Shu^* (2015) Lactobacillus Acidophilus Attenuates Salmonella-induced Intestinal inflammation via TGF-β signaling. BMC Microbiology 15(1):203 (IF: 3.605, 62/137, MICROBIOLOGY)

36.   PF Liu^#, CM Leung^#, YH Chang, JS Cheng, JJ Chen, CJWeng, KW Tsai, CJ Hsu, YC Liu, PC Hsu, HW Pan^*, CW Shu^* (2014) ATG4B Promotes Colorectal Cancer Growth Independent of Autophagic Flux. Autophagy 10(8):1454-1465 (IF: 16.016, 14/195, CELL BIOLOGY)

37.   PF Liu, IF Huang, CW Shu^*, CM Huang^* (2013) Halitosis Vaccines Targeting FomA, a Biofilm-bridging Protein in Fusobacteria nucleatum. Current Molecular Medicine 13(8):1358-1367 (IF: 2.222, 111/140, MEDICINE, RESEARCH & EXPERIMENTAL)

38.   WS Chen, TW Chen, TH Yang, LY Hu, HW Pan, CM Leung, SC Li, MR Ho, CW Shu, PF Liu, SY Yu, YT Tu, WC Lin, TT Wu^*, KW Tsai^* (2013) Co-modulated Behavior and Effects of Differentially Expressed miRNA in Colorectal Cancer. BMC Genomics 14 (Suppl 5):S12 (SCI, IF: 3.969, 57/159, BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

39.   CW Shu^*, PF Liu, CM Huang^* (2012) High-Throughput Screening for Drug Discovery of Autophagy Modulators. Combinatorial Chemistry & High Throughput Screening 15(9):721-729 (SCI, IF:1.339, 54/74, CHEMISTRY, APPLIED)

40.   PF Liu, T Nakatsuji, W Zhu, RL Gallo, CM Huang^* (2011) Passive Immunoprotection Targeting a Secreted CAMP Factor of Propionibacterium acnes as a Novel Immunotherapeutic for Acne Vulgaris. Vaccine 29(17), 3230-3238 (IF: 3.641, 76/140, MEDICINE, RESEARCH & EXPERIMENTAL)

41.   PF Liu, WY Shi, WH Zhu, JW Smith, SL Hsieh, RL Gallo, CM Huang^* (2010) Vaccination Targeting Surface FomA of Fusobacterium nucleatum against Bacterial Co-Aggregation: Implication for Treatment of Periodontal Infection and Halitosis. Vaccine 28(19), 3496-3505 (IF: 3.641, 76/140, MEDICINE, RESEARCH & EXPERIMENTAL)

42.   CHs Chen, XQ Zhang, CW Lo, PF Liu, YT Liu, RL Gallo, MF Hsieh^*, RT Schooley^*, CM Huang^* (2010) The Essentiality of Alpha-2-Macroglobulin in Human Salivary Innate Immunity against New H1N1 Swine Origin Influenza A Virus. Proteomics 10(12), 2396-2401 (IF: 3.984, 23/77, BIOCHEMICAL RESEARCH METHODS)

43.   YK Wang, WC Chang, PF Liu, MK Hsiao, CT Lin, SM Lin, RL Pan^* (2010) Ovate Family Protein 1 as A Plant Ku70 Interacting Protein Involving in DNA Double-Strand Break Repair. Plant Molecular Biology 74(4-5), 453-466 (IF: 4.076, 43/235, PLANT SCIENCES)

44.   PF Liu, WH Zhu, CM Huang^* (2009) Vaccines and Photodynamic Therapies for Oral Microbial-Related Diseases. Current Drug Metabolism 10(1), 90-94 (IF: 3.731, 125/275, PHARMACOLOGY & PHARMACY)

45.   PF Liu, SK Haake, RL. Gallo, CM Huang^* (2009) A Novel Vaccine Targeting Fusobacterium nucleatum against Abscesses and Halitosis. Vaccine 27(10), 1589-1595 (IF: 3.641, 76/140, MEDICINE, RESEARCH & EXPERIMENTAL)

46.   PF Liu, CW Lo, CH Chen, MF Hsien, CM Huang^* (2009) Use of Nanoparticles as Therapy for Methicillin-Resistant Staphylococcus aureus Infections. Current Drug Metabolism 10 (8), 875-884. (IF: 3.731, 125/275, PHARMACOLOGY & PHARMACY)

47.   SH Hsu, YY Hsiao, PF Liu, SM Lin, YY Luo, RL Pan^* (2009) Purification, Characterization, and Spectral Analyses of Histidine-Tagged Vacuolar H+-Pyrophosphatase Expressed in Yeast. Botanical Studies 50, 291-301 (IF: 2.787, 81/235, PLANT SCIENCES)

48.   PF Liu, YK Wang, WC Chang, HY Chang, RL Pan^* (2008) Regulation of Arabidopsis thaliana Ku Genes at Different Developmental Stages under Heat Stress. Biochimica et Biophysica Acta- Gene Regulatory Mechanisms 1779 (6-7), 402-407 (IF: 4.490, 16/71, BIOPHYSICS)

49.   PF Liu, WC Chang, YK Wang, HY Chang, RL Pan^* (2008) Signaling Pathways Mediating the Suppression of Arabidopsis thaliana Ku Gene Expression by Abscisic Acid. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 1779(3), 164-174 (IF: 4.490, 16/71, BIOPHYSICS)

50.   JY Fang, PF Liu, CM Huang^* (2008) Decreasing Systemic Toxicity via Transdermal Delivery of Anticancer Drugs. Current Drug Metabolism 9(7), 592-597 (IF: 3.731, 125/275, PHARMACOLOGY & PHARMACY)

51.   CW Shu, FC Sun, JH Cho, CC Lin, PF Liu, PY Chen, MDT Chang, HW Fu, YK Lai^* (2008) GRP78 and Raf-1 Cooperatively Confer Resistance to Endoplasmic Reticulum Stress-Induced Apoptosis. Journal of Cellular Physiology 215, 627-635 (IF: 6.384, 7/81, PHYSIOLOGY)

52.   WC Chang^#, YK Wang^#, PF Liu, YF Tsai, LR Kong, CK Lin, CH Yang, RL Pan^* (2008) Regulation of Ku Gene Promoters in Arabidopsis by Hormones and Stress. Functional Plant Biology 35, 265-280 (IF: 3.101, 70/235, PLANT SCIENCE)

53.   PF Liu, WC Chang, YK Wang, SB Munisamy, SH Hsu, HY Chang, SH Wu, RL Pan^* (2007) Differential regulation of Ku gene expression in etiolated mung bean hypocotyls by auxins. Biochimica et Biophysica Acta- Gene Regulatory Mechanisms 1769(7-8), 443-454 (IF: 4.490, 16/71, BIOPHYSICS)

54.   YY Hsiao, YJ Pan, SH Hsu, YT Huang, TH Liu, CH Lee, CH Lee, PF Liu, WC Chang, YK Wang, LF Chien, RL Pan^* (2007) Functional roles of arginine residues in mung bean vacuolar H+-pyrophosphatase. Biochimica et Biophysica Acta- Bioenergetics 1767, 965-973 (IF: 3.991, 21/71, BIOPHYSICS)

55.   SY Kuo, LF Chien, RC Van, KH Yan, PF Liu, WC Chang, JK Wang, RL Pan^* (2005) Purification and Subunit Determination of H+-Pyrophosphatase from Endoplasmic Reticulum-Enriched Vesicles of Mung Bean Seedlings. Plant Science 169, 847-853 (IF: 4.729, 26/235, PLANT SCIENCES)

56.   SY Kuo, LF Chien, YY Hsiao, RC Van, KH Yan, PF Liu, SJ Mao, RL Pan^* (2005) Proton Pumping Inorganic Pyrophosphatase of Endoplasmic Reticulum-Enriched Vesicles from Etiolated Mung Bean eedlings. Journal of Plant Physiology 162, 129-138 (IF: 3.549, 55/235, PLANT SCIENCES)

57.   KH Yan, PF Liu, HT Tzeng, WC Chang, WG Chou, RL Pan^* (2004) Characterization of DNA End-Binding Activities in Higher Plants. Plant Physiology and Biochemistry 42, 617-622 (IF: 4.270, 33/235, PLANT SCIENCES)

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