Associate Professor Chang, Yung-Fu
E-mail:m795003@kmu.edu.tw
Education:
Ph D, Graduate Institute of Medicine, Kaohsiung Medical University, , R.O.C.
Courses Offered:
Techniques in Biotechnology, Biochemistry Laboratory, Readings of English Biomedical Journals, General Biology, General Biology Laboratory
Specialty:
Biochemistry, Molecular Biology
Academic Interests:
To investigate the mechanisms of survival motor neuron (SMN) splicing
Publications:

  1. Chang, Y.-F., Tong, W.-H., and Yuo, C.-Y., 1995. Expression of a Drosophila cell death protein in E.coli and mammalian cells. The 10th Joint Ann. Conf.Biomed. Sci., Taipei, Taiwan.
  2. Chang, Y.-F., Tseng, C.-S., and Yuo, C.-Y., 1996. Expression and functional studies of Drosophila cell death protein, Reaper. Fourth Symposium on Recent Advance in Cellular and Molecular Biology, Kenting, Taiwan. 
  3. Chang, Y.-F., Tseng, C.-S., and Yuo, C.-Y., 1996. Drosophila cell death protein, Reaper, is expressed in embryos as a doublet. The 11th Joint Ann. Conf.Biomed. Sci., Taipei, Taiwan. 
  4. Cheng CM, Chang YF, Yuo CY*. Sequence of a human E2F-4 pseudogene with shortened AGC trinucleotide repeats. 1997, Kaohsiung J Med Sci. 13(7):448-52. 
  5. Cheng CM, Huang SP, Chang YF, Chung WY, Yuo CY*. The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1. 2003, Biochem. Biophys. Res. Commun. 30;305(2):359-64. (SCI, IF 2.935, BIOPHYSICS 18/63, BIOCHEMISTRY & MOLECULAR BIOLOGY 103/260) 
  6. Chang YF, Wei J, Liu X, Chen YH, Layne MD, Yet SF*. Identification of a CArG-independent region of the cysteine-rich protein 2 promoter that directs expression in the developing vasculature. 2003,Am J Physiol Heart Circ Physiol.285(4):H1675-83.(SCI, IF 3.369, CARDIAC & CARDIOVASCULAR SYSTEMS 8/66, PHYSIOLOGY 14/73, PERIPHERAL VASCULAR DISEASE 11/52 ) 
  7. Lee, Y.-H., Cheng, C.-M., Chang, Y.-F., Wang, T.-Y., and Yuo, C.-Y.*. Apoptin T108 phosphorylation is not required for its tumor-specific nuclear localization but partially affects its apoptotic activity. 2007. Biochem. Biophys. Res. Commun. 354(2):391-5. (SCI, IF 3.000, BIOPHYSICS 21/65, BIOCHEMISTRY & MOLECULAR BIOLOGY 97/261) 
  8. Liang WC, Yuo CY, Chang JG, Chen YC, Chang YF, Wang HY, Ju YH, Chiou SS, Jong YJ*. The effect of hydroxyurea in spinal muscular atrophy cells and patients. 2008. J Neurol Sci.268(1-2):87-94. (SCI, IF 2.412, CLINICAL NEUROLOGY 50/146)
  9. Wang CC, Chang JG, Ferrance J, Chen HY, You CY, Chang YF, Jong YJ, Wu SM*, Yeh CH. Quantification of SMN1 and SMN2 genes by capillary electrophoresis for diagnosis of spinal muscular atrophy. 2008. Electrophoresis. 29(13):2904-11. (SCI, IF 3.609, CHEMISTRY, ANALYTICAL, 6/70, BIOCHEMICAL RESEARCH METHODS 16/60 ) 
  10. Chang FR, Hsieh YC, Chang YF, Lee KH, Wu YC, Chang LK*. Inhibition of the Epstein-Barr virus lytic cycle by moronic acid. 2010. Antiviral Res. 85(3):490-5. (SCI, IF 3.613 
  11. Liu ST, Young GC, Lee YC, Chang YF*. A preliminary report on the toxicity of arecoline on early pregnancy in mice. 2011. Food Chem Toxicol. 49(1):144-148. (SCI, IF 2.114, FOOD SCIENCE & TECHNOLOGY 22/118, TOXICOLOGY 42/77) 
  12. Ting-Yuan Liu, Chung-Yee Yuo, Cheng-Hsing Kao, Chao-Neng Tseng, Yuh-Jyh Jong, Jan-Gowth Chang , Shou-Mei Wu, Yung-Fu Chang*. Hydrogen peroxide decreases the survival rate of HeLa cells with stable knockdown of SMN protein. 2011. Kaohsiung J Med Sci. 27(3):102-7. (SCI, IF 0.607, MEDICINE, RESEARCH & EXPERIMENTAL 84/93) 
  13. Yung-Fu Chang, Ting-Yuan Liu, Shao-Tung Liu, Chao-Neng Tseng *. Arecoline inhibits myogenic differentiation of C2C12 myoblasts by reducing STAT3 phosphorylation. 2012. Food Chem. Toxicol. 50(10):3433-3439. SCI, IF (2011) 2.999 
  14. Yung-Fu Chang, Hui-Ju Chou, Ying-Cheng Yen, Chiu-Chin Lu, Hurng-Wern Huang, Chung-Lung Cho, Hsueh-Wei Chang, Chao-Neng Tseng*. Agrin induces Association of Chrna1 mRNA and Nicotinic Acetylcholine Receptor in C2C12 Myotubes. 2012. FEBS lett. 21;586(19):3111-6. SCI, IF (2011) 3.538 
  15. Yung-Fu Chang*, Ting-Yuan Liu, Shao-Tung Liu.Arecoline inhibits and destabilizes agrin-induced acetylcholine receptor cluster formation in C2C12 myotubes. 2013. Food Chem. Toxicol. 60: 391-6. SCI, IF (2012) 3.010 
  16. Chao-Neng Tseng, Chien-Fu Huang, Chung-Lung Cho, Hsueh-Wei Chang, Chao-Wei Huang, Chien-Chih Chiu*, Yung-Fu Chang*. Brefeldin A Effectively Inhibits Cancer Stem Cell Properties and MMP-9 Activity in Human Colorectal Cancer Colo 205 cells. 2013. Molecules. 18(9), 10242-10253. SCI, IF (2012) 2.428 
  17. Chao-Neng Tseng, Chung-Lung Cho, Tzan-Wen Chen, Chien-Chih Chiu, Hsueh-Wei Chang, Fang-Rong Chang*, Yung-Fu Chang*. Brefeldin A inhibits Cancer Stem Cell Properties in Human Lung Cancer Cells. 2013. Curr. Signal Transduct. Ther. 8(2):113-118. SCI, IF (2012) 0.446
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